A macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium

A macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium

Salmonella Typhimurium replicates within host phagocytes. Here, the authors show that a known psychoactive drug (metergoline) inhibits growth of the pathogen in macrophages, disrupts the proton motive force at the bacterial cytoplasmic membrane, and extends animal survival during systemic infection.

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Detalles Bibliográficos
Autores principales: Michael J. Ellis, Caressa N. Tsai, Jarrod W. Johnson, Shawn French, Wael Elhenawy, Steffen Porwollik, Helene Andrews-Polymenis, Michael McClelland, Jakob Magolan, Brian K. Coombes, Eric D. Brown
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/d85977a7a0ee4df7ad240d73758c419e
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https://doaj.org/article/d85977a7a0ee4df7ad240d73758c419e

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