A macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium

Salmonella Typhimurium replicates within host phagocytes. Here, the authors show that a known psychoactive drug (metergoline) inhibits growth of the pathogen in macrophages, disrupts the proton motive force at the bacterial cytoplasmic membrane, and extends animal survival during systemic infection.

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Autores principales:	Michael J. Ellis, Caressa N. Tsai, Jarrod W. Johnson, Shawn French, Wael Elhenawy, Steffen Porwollik, Helene Andrews-Polymenis, Michael McClelland, Jakob Magolan, Brian K. Coombes, Eric D. Brown
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d85977a7a0ee4df7ad240d73758c419e
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spelling	oai:doaj.org-article:d85977a7a0ee4df7ad240d73758c419e2021-12-02T16:58:01ZA macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium10.1038/s41467-018-08190-x2041-1723https://doaj.org/article/d85977a7a0ee4df7ad240d73758c419e2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08190-xhttps://doaj.org/toc/2041-1723Salmonella Typhimurium replicates within host phagocytes. Here, the authors show that a known psychoactive drug (metergoline) inhibits growth of the pathogen in macrophages, disrupts the proton motive force at the bacterial cytoplasmic membrane, and extends animal survival during systemic infection.Michael J. EllisCaressa N. TsaiJarrod W. JohnsonShawn FrenchWael ElhenawySteffen PorwollikHelene Andrews-PolymenisMichael McClellandJakob MagolanBrian K. CoombesEric D. BrownNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael J. Ellis Caressa N. Tsai Jarrod W. Johnson Shawn French Wael Elhenawy Steffen Porwollik Helene Andrews-Polymenis Michael McClelland Jakob Magolan Brian K. Coombes Eric D. Brown A macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium
description	Salmonella Typhimurium replicates within host phagocytes. Here, the authors show that a known psychoactive drug (metergoline) inhibits growth of the pathogen in macrophages, disrupts the proton motive force at the bacterial cytoplasmic membrane, and extends animal survival during systemic infection.
format	article
author	Michael J. Ellis Caressa N. Tsai Jarrod W. Johnson Shawn French Wael Elhenawy Steffen Porwollik Helene Andrews-Polymenis Michael McClelland Jakob Magolan Brian K. Coombes Eric D. Brown
author_facet	Michael J. Ellis Caressa N. Tsai Jarrod W. Johnson Shawn French Wael Elhenawy Steffen Porwollik Helene Andrews-Polymenis Michael McClelland Jakob Magolan Brian K. Coombes Eric D. Brown
author_sort	Michael J. Ellis
title	A macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium
title_short	A macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium
title_full	A macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium
title_fullStr	A macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium
title_full_unstemmed	A macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium
title_sort	macrophage-based screen identifies antibacterial compounds selective for intracellular salmonella typhimurium
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/d85977a7a0ee4df7ad240d73758c419e
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A macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium

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