Aggregated transthyretin is specifically packaged into placental nano-vesicles in preeclampsia

Abstract In preeclampsia, the serum levels of transthyretin, a carrier protein for thyroxine, are elevated. Transthyretin isolated from preeclamptic serum is also aggregated and can induce preeclampsia-like symptoms in pregnant IL10−/− mice. Using western blotting, immunofluorescence, ELISA and qRT-...

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Bibliographic Details
Main Authors: Mancy Tong, Shi-bin Cheng, Qi Chen, Joana DeSousa, Peter R. Stone, Joanna L. James, Lawrence W. Chamley, Surendra Sharma
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
R
Q
Online Access:https://doaj.org/article/d86da9a98d17490480dbca830c152fcc
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