Aqueous and pH dependent coacervation method for taste masking of paracetamol via amorphous solid dispersion formation

Abstract Taste masking of paracetamol was achieved by preparing amorphous solid dispersion (ASD) using modified coacervation method. The method is based on dissolving the drug and polymeric carrier in water adjusted to certain pH level. Then, precipitation of ASD granules is performed by gradually c...

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Autores principales:	Basheer Al-kasmi, M. H. D. Bashir Alsirawan, Anant Paradkar, Abdul-Hakim Nattouf, Hind El-Zein
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d89fa4cc4d8840dab3e9526388ae31af
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spelling	oai:doaj.org-article:d89fa4cc4d8840dab3e9526388ae31af2021-12-02T17:20:11ZAqueous and pH dependent coacervation method for taste masking of paracetamol via amorphous solid dispersion formation10.1038/s41598-021-88312-62045-2322https://doaj.org/article/d89fa4cc4d8840dab3e9526388ae31af2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88312-6https://doaj.org/toc/2045-2322Abstract Taste masking of paracetamol was achieved by preparing amorphous solid dispersion (ASD) using modified coacervation method. The method is based on dissolving the drug and polymeric carrier in water adjusted to certain pH level. Then, precipitation of ASD granules is performed by gradually changing pH level. Therefore, the chosen drug and polymer should obtain appropriate acidic or basic groups to enable pH-dependent solvation. Moreover, using solubility enhancing additives such as sodium lauryl sulphate (SLS) and low viscosity polyethylene glycol (PEG 400) found to be essential in aiding drug/polymer aqueous solvation which enhanced amorphization, hence taste masking and drug loading. Solid dispersion between Paracetamol and Eudragit E was formed and that proved by FT-IR, DSC, PXRD and SEM. Also, Paracetamol was released after 2 min in 0.1 N hydrochloric acid medium and the taste of masking forms are accepted from all volunteers. Modified coacervation method does not involve organic solvents, high temperatures, or sophisticated instruments commonly used in taste masking methods. Using PEG 400 resulted in significantly higher drug loading and dissolution rate compared to SLS granules. Moreover, using previously reported scoring system for the evaluation of taste masking methods shows that pH dependent coacervation obtained high scoring over common methods and thus display a robust potential for industrial applications.Basheer Al-kasmiM. H. D. Bashir AlsirawanAnant ParadkarAbdul-Hakim NattoufHind El-ZeinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Basheer Al-kasmi M. H. D. Bashir Alsirawan Anant Paradkar Abdul-Hakim Nattouf Hind El-Zein Aqueous and pH dependent coacervation method for taste masking of paracetamol via amorphous solid dispersion formation
description	Abstract Taste masking of paracetamol was achieved by preparing amorphous solid dispersion (ASD) using modified coacervation method. The method is based on dissolving the drug and polymeric carrier in water adjusted to certain pH level. Then, precipitation of ASD granules is performed by gradually changing pH level. Therefore, the chosen drug and polymer should obtain appropriate acidic or basic groups to enable pH-dependent solvation. Moreover, using solubility enhancing additives such as sodium lauryl sulphate (SLS) and low viscosity polyethylene glycol (PEG 400) found to be essential in aiding drug/polymer aqueous solvation which enhanced amorphization, hence taste masking and drug loading. Solid dispersion between Paracetamol and Eudragit E was formed and that proved by FT-IR, DSC, PXRD and SEM. Also, Paracetamol was released after 2 min in 0.1 N hydrochloric acid medium and the taste of masking forms are accepted from all volunteers. Modified coacervation method does not involve organic solvents, high temperatures, or sophisticated instruments commonly used in taste masking methods. Using PEG 400 resulted in significantly higher drug loading and dissolution rate compared to SLS granules. Moreover, using previously reported scoring system for the evaluation of taste masking methods shows that pH dependent coacervation obtained high scoring over common methods and thus display a robust potential for industrial applications.
format	article
author	Basheer Al-kasmi M. H. D. Bashir Alsirawan Anant Paradkar Abdul-Hakim Nattouf Hind El-Zein
author_facet	Basheer Al-kasmi M. H. D. Bashir Alsirawan Anant Paradkar Abdul-Hakim Nattouf Hind El-Zein
author_sort	Basheer Al-kasmi
title	Aqueous and pH dependent coacervation method for taste masking of paracetamol via amorphous solid dispersion formation
title_short	Aqueous and pH dependent coacervation method for taste masking of paracetamol via amorphous solid dispersion formation
title_full	Aqueous and pH dependent coacervation method for taste masking of paracetamol via amorphous solid dispersion formation
title_fullStr	Aqueous and pH dependent coacervation method for taste masking of paracetamol via amorphous solid dispersion formation
title_full_unstemmed	Aqueous and pH dependent coacervation method for taste masking of paracetamol via amorphous solid dispersion formation
title_sort	aqueous and ph dependent coacervation method for taste masking of paracetamol via amorphous solid dispersion formation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d89fa4cc4d8840dab3e9526388ae31af
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Aqueous and pH dependent coacervation method for taste masking of paracetamol via amorphous solid dispersion formation

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