In situ identification and G4-PPI-His-Mal-dendrimer-induced reduction of early-stage amyloid aggregates in Alzheimer’s disease transgenic mice using synchrotron-based infrared imaging

Abstract Amyloid plaques composed of Aβ amyloid peptides and neurofibrillary tangles are a pathological hallmark of Alzheimer Disease. In situ identification of early-stage amyloid aggregates in Alzheimer’s disease is relevant for their importance as potential targets for effective drugs. Synchrotro...

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Autores principales:	Núria Benseny-Cases, Elena Álvarez-Marimon, Ester Aso, Margarita Carmona, Oxana Klementieva, Dietmar Appelhans, Isidre Ferrer, Josep Cladera
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d8a5ad123a7a4b33aa19c03be9c3699c
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spelling	oai:doaj.org-article:d8a5ad123a7a4b33aa19c03be9c3699c2021-12-02T15:15:40ZIn situ identification and G4-PPI-His-Mal-dendrimer-induced reduction of early-stage amyloid aggregates in Alzheimer’s disease transgenic mice using synchrotron-based infrared imaging10.1038/s41598-021-96379-42045-2322https://doaj.org/article/d8a5ad123a7a4b33aa19c03be9c3699c2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96379-4https://doaj.org/toc/2045-2322Abstract Amyloid plaques composed of Aβ amyloid peptides and neurofibrillary tangles are a pathological hallmark of Alzheimer Disease. In situ identification of early-stage amyloid aggregates in Alzheimer’s disease is relevant for their importance as potential targets for effective drugs. Synchrotron-based infrared imaging is here used to identify early-stage oligomeric/granular aggregated amyloid species in situ in the brain of APP/PS1 transgenic mice for the first time. Also, APP/PS1 mice show fibrillary aggregates at 6 and 12 months. A significant decreased burden of early-stage aggregates and fibrillary aggregates is obtained following treatment with poly(propylene imine) dendrimers with histidine-maltose shell (a neurodegenerative protector) in 6-month-old APP/PS1 mice, thus demonstrating their putative therapeutic properties of in AD models. Identification, localization, and characterization using infrared imaging of these non-fibrillary species in the cerebral cortex at early stages of AD progression in transgenic mice point to their relevance as putative pharmacological targets. No less important, early detection of these structures may be useful in the search for markers for non-invasive diagnostic techniques.Núria Benseny-CasesElena Álvarez-MarimonEster AsoMargarita CarmonaOxana KlementievaDietmar AppelhansIsidre FerrerJosep CladeraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Núria Benseny-Cases Elena Álvarez-Marimon Ester Aso Margarita Carmona Oxana Klementieva Dietmar Appelhans Isidre Ferrer Josep Cladera In situ identification and G4-PPI-His-Mal-dendrimer-induced reduction of early-stage amyloid aggregates in Alzheimer’s disease transgenic mice using synchrotron-based infrared imaging
description	Abstract Amyloid plaques composed of Aβ amyloid peptides and neurofibrillary tangles are a pathological hallmark of Alzheimer Disease. In situ identification of early-stage amyloid aggregates in Alzheimer’s disease is relevant for their importance as potential targets for effective drugs. Synchrotron-based infrared imaging is here used to identify early-stage oligomeric/granular aggregated amyloid species in situ in the brain of APP/PS1 transgenic mice for the first time. Also, APP/PS1 mice show fibrillary aggregates at 6 and 12 months. A significant decreased burden of early-stage aggregates and fibrillary aggregates is obtained following treatment with poly(propylene imine) dendrimers with histidine-maltose shell (a neurodegenerative protector) in 6-month-old APP/PS1 mice, thus demonstrating their putative therapeutic properties of in AD models. Identification, localization, and characterization using infrared imaging of these non-fibrillary species in the cerebral cortex at early stages of AD progression in transgenic mice point to their relevance as putative pharmacological targets. No less important, early detection of these structures may be useful in the search for markers for non-invasive diagnostic techniques.
format	article
author	Núria Benseny-Cases Elena Álvarez-Marimon Ester Aso Margarita Carmona Oxana Klementieva Dietmar Appelhans Isidre Ferrer Josep Cladera
author_facet	Núria Benseny-Cases Elena Álvarez-Marimon Ester Aso Margarita Carmona Oxana Klementieva Dietmar Appelhans Isidre Ferrer Josep Cladera
author_sort	Núria Benseny-Cases
title	In situ identification and G4-PPI-His-Mal-dendrimer-induced reduction of early-stage amyloid aggregates in Alzheimer’s disease transgenic mice using synchrotron-based infrared imaging
title_short	In situ identification and G4-PPI-His-Mal-dendrimer-induced reduction of early-stage amyloid aggregates in Alzheimer’s disease transgenic mice using synchrotron-based infrared imaging
title_full	In situ identification and G4-PPI-His-Mal-dendrimer-induced reduction of early-stage amyloid aggregates in Alzheimer’s disease transgenic mice using synchrotron-based infrared imaging
title_fullStr	In situ identification and G4-PPI-His-Mal-dendrimer-induced reduction of early-stage amyloid aggregates in Alzheimer’s disease transgenic mice using synchrotron-based infrared imaging
title_full_unstemmed	In situ identification and G4-PPI-His-Mal-dendrimer-induced reduction of early-stage amyloid aggregates in Alzheimer’s disease transgenic mice using synchrotron-based infrared imaging
title_sort	in situ identification and g4-ppi-his-mal-dendrimer-induced reduction of early-stage amyloid aggregates in alzheimer’s disease transgenic mice using synchrotron-based infrared imaging
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d8a5ad123a7a4b33aa19c03be9c3699c
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In situ identification and G4-PPI-His-Mal-dendrimer-induced reduction of early-stage amyloid aggregates in Alzheimer’s disease transgenic mice using synchrotron-based infrared imaging

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