Discovery of unique lanthionine synthetases reveals new mechanistic and evolutionary insights.

Lantibiotic synthetases are remarkable biocatalysts generating conformationally constrained peptides with a variety of biological activities by repeatedly utilizing two simple posttranslational modification reactions: dehydration of Ser/Thr residues and intramolecular addition of Cys thiols to the r...

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Autores principales: Yuki Goto, Bo Li, Jan Claesen, Yanxiang Shi, Mervyn J Bibb, Wilfred A van der Donk
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2010
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Acceso en línea:https://doaj.org/article/d8ade89d6f5344008dc28ab3ce01cc01
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