Targeting of somatic hypermutation by immunoglobulin enhancer and enhancer-like sequences.
Somatic hypermutation (SH) generates point mutations within rearranged immunoglobulin (Ig) genes of activated B cells, providing genetic diversity for the affinity maturation of antibodies. SH requires the activation-induced cytidine deaminase (AID) protein and transcription of the mutation target s...
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Auteurs principaux: | , , , , |
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Format: | article |
Langue: | EN |
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Public Library of Science (PLoS)
2014
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Accès en ligne: | https://doaj.org/article/d8c75f8713464da9bd7f8ad340ca1263 |
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