Upregulation of CD47 Is a Host Checkpoint Response to Pathogen Recognition

Upregulation of CD47 Is a Host Checkpoint Response to Pathogen Recognition

ABSTRACT It is well understood that the adaptive immune response to infectious agents includes a modulating suppressive component as well as an activating component. We now show that the very early innate response also has an immunosuppressive component. Infected cells upregulate the CD47 “don’t eat...

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Main Authors: Michal Caspi Tal, Laughing Bear Torrez Dulgeroff, Lara Myers, Lamin B. Cham, Katrin D. Mayer-Barber, Andrea C. Bohrer, Ehydel Castro, Ying Ying Yiu, Cesar Lopez Angel, Ed Pham, Aaron B. Carmody, Ronald J. Messer, Eric Gars, Jens Kortmann, Maxim Markovic, Michaela Hasenkrug, Karin E. Peterson, Clayton W. Winkler, Tyson A. Woods, Paige Hansen, Sarah Galloway, Dhananjay Wagh, Benjamin J. Fram, Thai Nguyen, Daniel Corey, Raja Sab Kalluru, Niaz Banaei, Jayakumar Rajadas, Denise M. Monack, Aijaz Ahmed, Debashis Sahoo, Mark M. Davis, Jeffrey S. Glenn, Tom Adomati, Karl S. Lang, Irving L. Weissman, Kim J. Hasenkrug
Format: article
Language:EN
Published: American Society for Microbiology 2020
Subjects:
CD47
host response
immune checkpoint
innate immunity
pathogen recognition receptors
Microbiology
QR1-502
Online Access:https://doaj.org/article/d8f71f31b4e248b893caeb967d0cb234
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https://doaj.org/article/d8f71f31b4e248b893caeb967d0cb234

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