Revisiting G3BP1 as a RasGAP binding protein: sensitization of tumor cells to chemotherapy by the RasGAP 317-326 sequence does not involve G3BP1.

RasGAP is a multifunctional protein that controls Ras activity and that is found in chromosomal passenger complexes. It also negatively or positively regulates apoptosis depending on the extent of its cleavage by caspase-3. RasGAP has been reported to bind to G3BP1 (RasGAP SH3-domain-binding protein...

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Auteurs principaux: Alessandro Annibaldi, Aline Dousse, Sophie Martin, Jamal Tazi, Christian Widmann
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2011
Sujets:
R
Q
Accès en ligne:https://doaj.org/article/d91742c6b94342bf9331a8d35c821c18
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