Directed evolution of prenylated FMN-dependent Fdc supports efficient in vivo isobutene production

Isobutene is a high value gaseous alkene that is widely used as fuel additive and a chemical building block. Here, the authors report an alternative pathway for isobutene bioproduction by directed evolution of prenylated FMN-dependent ferulic acid decarboxylase.

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Autores principales:	Annica Saaret, Benoît Villiers, François Stricher, Macha Anissimova, Mélodie Cadillon, Reynard Spiess, Sam Hay, David Leys
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d96751d628eb4409a64c70cfafc944c0
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spelling	oai:doaj.org-article:d96751d628eb4409a64c70cfafc944c02021-12-02T17:42:11ZDirected evolution of prenylated FMN-dependent Fdc supports efficient in vivo isobutene production10.1038/s41467-021-25598-02041-1723https://doaj.org/article/d96751d628eb4409a64c70cfafc944c02021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25598-0https://doaj.org/toc/2041-1723Isobutene is a high value gaseous alkene that is widely used as fuel additive and a chemical building block. Here, the authors report an alternative pathway for isobutene bioproduction by directed evolution of prenylated FMN-dependent ferulic acid decarboxylase.Annica SaaretBenoît VilliersFrançois StricherMacha AnissimovaMélodie CadillonReynard SpiessSam HayDavid LeysNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Annica Saaret Benoît Villiers François Stricher Macha Anissimova Mélodie Cadillon Reynard Spiess Sam Hay David Leys Directed evolution of prenylated FMN-dependent Fdc supports efficient in vivo isobutene production
description	Isobutene is a high value gaseous alkene that is widely used as fuel additive and a chemical building block. Here, the authors report an alternative pathway for isobutene bioproduction by directed evolution of prenylated FMN-dependent ferulic acid decarboxylase.
format	article
author	Annica Saaret Benoît Villiers François Stricher Macha Anissimova Mélodie Cadillon Reynard Spiess Sam Hay David Leys
author_facet	Annica Saaret Benoît Villiers François Stricher Macha Anissimova Mélodie Cadillon Reynard Spiess Sam Hay David Leys
author_sort	Annica Saaret
title	Directed evolution of prenylated FMN-dependent Fdc supports efficient in vivo isobutene production
title_short	Directed evolution of prenylated FMN-dependent Fdc supports efficient in vivo isobutene production
title_full	Directed evolution of prenylated FMN-dependent Fdc supports efficient in vivo isobutene production
title_fullStr	Directed evolution of prenylated FMN-dependent Fdc supports efficient in vivo isobutene production
title_full_unstemmed	Directed evolution of prenylated FMN-dependent Fdc supports efficient in vivo isobutene production
title_sort	directed evolution of prenylated fmn-dependent fdc supports efficient in vivo isobutene production
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d96751d628eb4409a64c70cfafc944c0
work_keys_str_mv	AT annicasaaret directedevolutionofprenylatedfmndependentfdcsupportsefficientinvivoisobuteneproduction AT benoitvilliers directedevolutionofprenylatedfmndependentfdcsupportsefficientinvivoisobuteneproduction AT francoisstricher directedevolutionofprenylatedfmndependentfdcsupportsefficientinvivoisobuteneproduction AT machaanissimova directedevolutionofprenylatedfmndependentfdcsupportsefficientinvivoisobuteneproduction AT melodiecadillon directedevolutionofprenylatedfmndependentfdcsupportsefficientinvivoisobuteneproduction AT reynardspiess directedevolutionofprenylatedfmndependentfdcsupportsefficientinvivoisobuteneproduction AT samhay directedevolutionofprenylatedfmndependentfdcsupportsefficientinvivoisobuteneproduction AT davidleys directedevolutionofprenylatedfmndependentfdcsupportsefficientinvivoisobuteneproduction
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Directed evolution of prenylated FMN-dependent Fdc supports efficient in vivo isobutene production

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