The NRTIs lamivudine, stavudine and zidovudine have reduced HIV-1 inhibitory activity in astrocytes.

The NRTIs lamivudine, stavudine and zidovudine have reduced HIV-1 inhibitory activity in astrocytes.

HIV-1 establishes infection in astrocytes and macroage-lineage cells of the central nervous system (CNS). Certain antiretroviral drugs (ARVs) can penetrate the CNS, and are therefore often used in neurologically active combined antiretroviral therapy (Neuro-cART) regimens, but their relative activit...

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Bibliographic Details
Main Authors: Lachlan R Gray, Gilda Tachedjian, Anne M Ellett, Michael J Roche, Wan-Jung Cheng, Gilles J Guillemin, Bruce J Brew, Stuart G Turville, Steve L Wesselingh, Paul R Gorry, Melissa J Churchill
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2013
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/d97c6377d27544618061aac3fbdc631d
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https://doaj.org/article/d97c6377d27544618061aac3fbdc631d

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