Mitochondrial Targeting and pH-Responsive Nanogels for Co-Delivery of Lonidamine and Paclitaxel to Conquer Drug Resistance

Multidrug resistance (MDR) is one of the leading causes of the failure of cancer chemotherapy and mainly attributed to the overexpression of drug efflux transporters in cancer cells, which is dependent on adenosine triphosphate (ATP). To overcome this phenomenon, herein, a mitochondrial-directed pH-...

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Autores principales: Enping Chen, Ting Wang, Junmei Zhang, Xiang Zhou, Yafan Niu, Fu Liu, Yinan Zhong, Dechun Huang, Wei Chen
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
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Acceso en línea:https://doaj.org/article/d9b241e559a34da69d057c009856dbc9
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