Aromatic side-chain conformational switch on the surface of the RNA Recognition Motif enables RNA discrimination

The RNA Recognition Motif (RRM) is the most ubiquitous RNA binding domain. Here the authors combined NMR and molecular dynamics simulations and show that the RRM RNA binding surface exists in different states and that a conformational switch of aromatic side-chains fine-tunes sequence specific bindi...

Full description

Saved in:
Bibliographic Details
Main Authors: Nana Diarra dit Konté, Miroslav Krepl, Fred F. Damberger, Nina Ripin, Olivier Duss, Jiří Šponer, Frédéric H.-T. Allain
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Q
Online Access:https://doaj.org/article/d9c2bfca189b4e37a1032253df873e05
Tags: Add Tag
No Tags, Be the first to tag this record!