Aromatic side-chain conformational switch on the surface of the RNA Recognition Motif enables RNA discrimination

The RNA Recognition Motif (RRM) is the most ubiquitous RNA binding domain. Here the authors combined NMR and molecular dynamics simulations and show that the RRM RNA binding surface exists in different states and that a conformational switch of aromatic side-chains fine-tunes sequence specific bindi...

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Autores principales:	Nana Diarra dit Konté, Miroslav Krepl, Fred F. Damberger, Nina Ripin, Olivier Duss, Jiří Šponer, Frédéric H.-T. Allain
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d9c2bfca189b4e37a1032253df873e05
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spelling	oai:doaj.org-article:d9c2bfca189b4e37a1032253df873e052021-12-02T17:06:06ZAromatic side-chain conformational switch on the surface of the RNA Recognition Motif enables RNA discrimination10.1038/s41467-017-00631-32041-1723https://doaj.org/article/d9c2bfca189b4e37a1032253df873e052017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00631-3https://doaj.org/toc/2041-1723The RNA Recognition Motif (RRM) is the most ubiquitous RNA binding domain. Here the authors combined NMR and molecular dynamics simulations and show that the RRM RNA binding surface exists in different states and that a conformational switch of aromatic side-chains fine-tunes sequence specific binding affinities.Nana Diarra dit KontéMiroslav KreplFred F. DambergerNina RipinOlivier DussJiří ŠponerFrédéric H.-T. AllainNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nana Diarra dit Konté Miroslav Krepl Fred F. Damberger Nina Ripin Olivier Duss Jiří Šponer Frédéric H.-T. Allain Aromatic side-chain conformational switch on the surface of the RNA Recognition Motif enables RNA discrimination
description	The RNA Recognition Motif (RRM) is the most ubiquitous RNA binding domain. Here the authors combined NMR and molecular dynamics simulations and show that the RRM RNA binding surface exists in different states and that a conformational switch of aromatic side-chains fine-tunes sequence specific binding affinities.
format	article
author	Nana Diarra dit Konté Miroslav Krepl Fred F. Damberger Nina Ripin Olivier Duss Jiří Šponer Frédéric H.-T. Allain
author_facet	Nana Diarra dit Konté Miroslav Krepl Fred F. Damberger Nina Ripin Olivier Duss Jiří Šponer Frédéric H.-T. Allain
author_sort	Nana Diarra dit Konté
title	Aromatic side-chain conformational switch on the surface of the RNA Recognition Motif enables RNA discrimination
title_short	Aromatic side-chain conformational switch on the surface of the RNA Recognition Motif enables RNA discrimination
title_full	Aromatic side-chain conformational switch on the surface of the RNA Recognition Motif enables RNA discrimination
title_fullStr	Aromatic side-chain conformational switch on the surface of the RNA Recognition Motif enables RNA discrimination
title_full_unstemmed	Aromatic side-chain conformational switch on the surface of the RNA Recognition Motif enables RNA discrimination
title_sort	aromatic side-chain conformational switch on the surface of the rna recognition motif enables rna discrimination
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d9c2bfca189b4e37a1032253df873e05
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Aromatic side-chain conformational switch on the surface of the RNA Recognition Motif enables RNA discrimination

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