Aromatic side-chain conformational switch on the surface of the RNA Recognition Motif enables RNA discrimination

The RNA Recognition Motif (RRM) is the most ubiquitous RNA binding domain. Here the authors combined NMR and molecular dynamics simulations and show that the RRM RNA binding surface exists in different states and that a conformational switch of aromatic side-chains fine-tunes sequence specific bindi...

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Autores principales: Nana Diarra dit Konté, Miroslav Krepl, Fred F. Damberger, Nina Ripin, Olivier Duss, Jiří Šponer, Frédéric H.-T. Allain
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/d9c2bfca189b4e37a1032253df873e05
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