Inhibitory peptide of mitochondrial μ-calpain protects against photoreceptor degeneration in rhodopsin transgenic S334ter and P23H rats.

Mitochondrial μ-calpain and apoptosis-inducing factor (AIF)-dependent photoreceptor cell death has been seen in several rat and mouse models of retinitis pigmentosa (RP). Previously, we demonstrated that the specific peptide inhibitor of mitochondrial μ-calpain, Tat-µCL, protected against retinal de...

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Autores principales: Taku Ozaki, Sei-ichi Ishiguro, Satoshi Hirano, Ayaka Baba, Tetsuro Yamashita, Hiroshi Tomita, Mitsuru Nakazawa
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/d9c9a4ab2b594670a3211839c808516b
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