Genome-wide gene-environment study identifies glutamate receptor gene GRIN2A as a Parkinson's disease modifier gene via interaction with coffee.

Genome-wide gene-environment study identifies glutamate receptor gene GRIN2A as a Parkinson's disease modifier gene via interaction with coffee.

Our aim was to identify genes that influence the inverse association of coffee with the risk of developing Parkinson's disease (PD). We used genome-wide genotype data and lifetime caffeinated-coffee-consumption data on 1,458 persons with PD and 931 without PD from the NeuroGenetics Research Con...

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Auteurs principaux: Taye H Hamza, Honglei Chen, Erin M Hill-Burns, Shannon L Rhodes, Jennifer Montimurro, Denise M Kay, Albert Tenesa, Victoria I Kusel, Patricia Sheehan, Muthukrishnan Eaaswarkhanth, Dora Yearout, Ali Samii, John W Roberts, Pinky Agarwal, Yvette Bordelon, Yikyung Park, Liyong Wang, Jianjun Gao, Jeffery M Vance, Kenneth S Kendler, Silviu-Alin Bacanu, William K Scott, Beate Ritz, John Nutt, Stewart A Factor, Cyrus P Zabetian, Haydeh Payami
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2011
Sujets:
Genetics
QH426-470
Accès en ligne:https://doaj.org/article/d9d8feb3c5a546248ccbec16104d890a
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Internet

https://doaj.org/article/d9d8feb3c5a546248ccbec16104d890a

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