Capture of associated targets on chromatin links long-distance chromatin looping to transcriptional coordination

Chromatin architecture is a key regulator of transcriptional processes, however current methods to investigate it have technical limitations. Here, the authors describe a novel chromatin capture technique, CATCH, which can be used to identify and characterize complex genomic interaction networks.

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Detalles Bibliográficos
Autores principales: Ryan J. Bourgo, Hari Singhal, Geoffrey L. Greene
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/d9d922e6f2af4de89e92707b4595c4a8
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Sumario:Chromatin architecture is a key regulator of transcriptional processes, however current methods to investigate it have technical limitations. Here, the authors describe a novel chromatin capture technique, CATCH, which can be used to identify and characterize complex genomic interaction networks.