Atypical plant homeodomain of UBR7 functions as an H2BK120Ub ligase and breast tumor suppressor
H2B monoubiquitination is implicated in oncogenesis. Here, the authors show that UBR7 PHD finger is a H2BK120 monoubiquitin ligase that acts a tumour suppressor in breast cancer by suppressing gene expression for EMT, while promoting expression of CDH4 which restrain WNT/β-cat pathway.
Saved in:
Main Authors: | , , , , , , , , , , , , , , , , |
---|---|
Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2019
|
Subjects: | |
Online Access: | https://doaj.org/article/d9e45b04af2247a480020df6e19b7638 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|