Atypical plant homeodomain of UBR7 functions as an H2BK120Ub ligase and breast tumor suppressor

H2B monoubiquitination is implicated in oncogenesis. Here, the authors show that UBR7 PHD finger is a H2BK120 monoubiquitin ligase that acts a tumour suppressor in breast cancer by suppressing gene expression for EMT, while promoting expression of CDH4 which restrain WNT/β-cat pathway.

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Autores principales: Santanu Adhikary, Deepavali Chakravarti, Christopher Terranova, Isha Sengupta, Mayinuer Maitituoheti, Anirban Dasgupta, Dushyant Kumar Srivastava, Junsheng Ma, Ayush T. Raman, Emily Tarco, Aysegul A. Sahin, Roland Bassett, Fei Yang, Coya Tapia, Siddhartha Roy, Kunal Rai, Chandrima Das
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Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/d9e45b04af2247a480020df6e19b7638
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spelling oai:doaj.org-article:d9e45b04af2247a480020df6e19b76382021-12-02T16:57:52ZAtypical plant homeodomain of UBR7 functions as an H2BK120Ub ligase and breast tumor suppressor10.1038/s41467-019-08986-52041-1723https://doaj.org/article/d9e45b04af2247a480020df6e19b76382019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08986-5https://doaj.org/toc/2041-1723H2B monoubiquitination is implicated in oncogenesis. Here, the authors show that UBR7 PHD finger is a H2BK120 monoubiquitin ligase that acts a tumour suppressor in breast cancer by suppressing gene expression for EMT, while promoting expression of CDH4 which restrain WNT/β-cat pathway.Santanu AdhikaryDeepavali ChakravartiChristopher TerranovaIsha SenguptaMayinuer MaitituohetiAnirban DasguptaDushyant Kumar SrivastavaJunsheng MaAyush T. RamanEmily TarcoAysegul A. SahinRoland BassettFei YangCoya TapiaSiddhartha RoyKunal RaiChandrima DasNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Santanu Adhikary
Deepavali Chakravarti
Christopher Terranova
Isha Sengupta
Mayinuer Maitituoheti
Anirban Dasgupta
Dushyant Kumar Srivastava
Junsheng Ma
Ayush T. Raman
Emily Tarco
Aysegul A. Sahin
Roland Bassett
Fei Yang
Coya Tapia
Siddhartha Roy
Kunal Rai
Chandrima Das
Atypical plant homeodomain of UBR7 functions as an H2BK120Ub ligase and breast tumor suppressor
description H2B monoubiquitination is implicated in oncogenesis. Here, the authors show that UBR7 PHD finger is a H2BK120 monoubiquitin ligase that acts a tumour suppressor in breast cancer by suppressing gene expression for EMT, while promoting expression of CDH4 which restrain WNT/β-cat pathway.
format article
author Santanu Adhikary
Deepavali Chakravarti
Christopher Terranova
Isha Sengupta
Mayinuer Maitituoheti
Anirban Dasgupta
Dushyant Kumar Srivastava
Junsheng Ma
Ayush T. Raman
Emily Tarco
Aysegul A. Sahin
Roland Bassett
Fei Yang
Coya Tapia
Siddhartha Roy
Kunal Rai
Chandrima Das
author_facet Santanu Adhikary
Deepavali Chakravarti
Christopher Terranova
Isha Sengupta
Mayinuer Maitituoheti
Anirban Dasgupta
Dushyant Kumar Srivastava
Junsheng Ma
Ayush T. Raman
Emily Tarco
Aysegul A. Sahin
Roland Bassett
Fei Yang
Coya Tapia
Siddhartha Roy
Kunal Rai
Chandrima Das
author_sort Santanu Adhikary
title Atypical plant homeodomain of UBR7 functions as an H2BK120Ub ligase and breast tumor suppressor
title_short Atypical plant homeodomain of UBR7 functions as an H2BK120Ub ligase and breast tumor suppressor
title_full Atypical plant homeodomain of UBR7 functions as an H2BK120Ub ligase and breast tumor suppressor
title_fullStr Atypical plant homeodomain of UBR7 functions as an H2BK120Ub ligase and breast tumor suppressor
title_full_unstemmed Atypical plant homeodomain of UBR7 functions as an H2BK120Ub ligase and breast tumor suppressor
title_sort atypical plant homeodomain of ubr7 functions as an h2bk120ub ligase and breast tumor suppressor
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/d9e45b04af2247a480020df6e19b7638
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