Atypical plant homeodomain of UBR7 functions as an H2BK120Ub ligase and breast tumor suppressor
H2B monoubiquitination is implicated in oncogenesis. Here, the authors show that UBR7 PHD finger is a H2BK120 monoubiquitin ligase that acts a tumour suppressor in breast cancer by suppressing gene expression for EMT, while promoting expression of CDH4 which restrain WNT/β-cat pathway.
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Nature Portfolio
2019
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oai:doaj.org-article:d9e45b04af2247a480020df6e19b76382021-12-02T16:57:52ZAtypical plant homeodomain of UBR7 functions as an H2BK120Ub ligase and breast tumor suppressor10.1038/s41467-019-08986-52041-1723https://doaj.org/article/d9e45b04af2247a480020df6e19b76382019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08986-5https://doaj.org/toc/2041-1723H2B monoubiquitination is implicated in oncogenesis. Here, the authors show that UBR7 PHD finger is a H2BK120 monoubiquitin ligase that acts a tumour suppressor in breast cancer by suppressing gene expression for EMT, while promoting expression of CDH4 which restrain WNT/β-cat pathway.Santanu AdhikaryDeepavali ChakravartiChristopher TerranovaIsha SenguptaMayinuer MaitituohetiAnirban DasguptaDushyant Kumar SrivastavaJunsheng MaAyush T. RamanEmily TarcoAysegul A. SahinRoland BassettFei YangCoya TapiaSiddhartha RoyKunal RaiChandrima DasNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019) |
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Science Q Santanu Adhikary Deepavali Chakravarti Christopher Terranova Isha Sengupta Mayinuer Maitituoheti Anirban Dasgupta Dushyant Kumar Srivastava Junsheng Ma Ayush T. Raman Emily Tarco Aysegul A. Sahin Roland Bassett Fei Yang Coya Tapia Siddhartha Roy Kunal Rai Chandrima Das Atypical plant homeodomain of UBR7 functions as an H2BK120Ub ligase and breast tumor suppressor |
description |
H2B monoubiquitination is implicated in oncogenesis. Here, the authors show that UBR7 PHD finger is a H2BK120 monoubiquitin ligase that acts a tumour suppressor in breast cancer by suppressing gene expression for EMT, while promoting expression of CDH4 which restrain WNT/β-cat pathway. |
format |
article |
author |
Santanu Adhikary Deepavali Chakravarti Christopher Terranova Isha Sengupta Mayinuer Maitituoheti Anirban Dasgupta Dushyant Kumar Srivastava Junsheng Ma Ayush T. Raman Emily Tarco Aysegul A. Sahin Roland Bassett Fei Yang Coya Tapia Siddhartha Roy Kunal Rai Chandrima Das |
author_facet |
Santanu Adhikary Deepavali Chakravarti Christopher Terranova Isha Sengupta Mayinuer Maitituoheti Anirban Dasgupta Dushyant Kumar Srivastava Junsheng Ma Ayush T. Raman Emily Tarco Aysegul A. Sahin Roland Bassett Fei Yang Coya Tapia Siddhartha Roy Kunal Rai Chandrima Das |
author_sort |
Santanu Adhikary |
title |
Atypical plant homeodomain of UBR7 functions as an H2BK120Ub ligase and breast tumor suppressor |
title_short |
Atypical plant homeodomain of UBR7 functions as an H2BK120Ub ligase and breast tumor suppressor |
title_full |
Atypical plant homeodomain of UBR7 functions as an H2BK120Ub ligase and breast tumor suppressor |
title_fullStr |
Atypical plant homeodomain of UBR7 functions as an H2BK120Ub ligase and breast tumor suppressor |
title_full_unstemmed |
Atypical plant homeodomain of UBR7 functions as an H2BK120Ub ligase and breast tumor suppressor |
title_sort |
atypical plant homeodomain of ubr7 functions as an h2bk120ub ligase and breast tumor suppressor |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/d9e45b04af2247a480020df6e19b7638 |
work_keys_str_mv |
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