Human cytomegalovirus-induced host protein citrullination is crucial for viral replication
Citrullination is a posttranslational modification of arginines. Here, the authors show that HCMV infection increases citrullination of host and virus proteins to promote infection and that citrullinated interferon-inducible protein IFIT1 is impaired in RNA binding, as a potential mechanism of evasi...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/d9f89f1cfaed42dc92c156e171d58d7e |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:d9f89f1cfaed42dc92c156e171d58d7e |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:d9f89f1cfaed42dc92c156e171d58d7e2021-12-02T17:14:22ZHuman cytomegalovirus-induced host protein citrullination is crucial for viral replication10.1038/s41467-021-24178-62041-1723https://doaj.org/article/d9f89f1cfaed42dc92c156e171d58d7e2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24178-6https://doaj.org/toc/2041-1723Citrullination is a posttranslational modification of arginines. Here, the authors show that HCMV infection increases citrullination of host and virus proteins to promote infection and that citrullinated interferon-inducible protein IFIT1 is impaired in RNA binding, as a potential mechanism of evasion.Gloria GriffanteFrancesca GugliesiSelina PasqueroValentina Dell’OsteMatteo BiolattiAri J. SalingerSantanu MondalPaul R. ThompsonEranthie WeerapanaRobert J. LebbinkJasper A. SoppeThomas StammingerVirginie GiraultAndreas PichlmairGábor OroszlánDonald M. CoenMarco De AndreaSanto LandolfoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Gloria Griffante Francesca Gugliesi Selina Pasquero Valentina Dell’Oste Matteo Biolatti Ari J. Salinger Santanu Mondal Paul R. Thompson Eranthie Weerapana Robert J. Lebbink Jasper A. Soppe Thomas Stamminger Virginie Girault Andreas Pichlmair Gábor Oroszlán Donald M. Coen Marco De Andrea Santo Landolfo Human cytomegalovirus-induced host protein citrullination is crucial for viral replication |
| description |
Citrullination is a posttranslational modification of arginines. Here, the authors show that HCMV infection increases citrullination of host and virus proteins to promote infection and that citrullinated interferon-inducible protein IFIT1 is impaired in RNA binding, as a potential mechanism of evasion. |
| format |
article |
| author |
Gloria Griffante Francesca Gugliesi Selina Pasquero Valentina Dell’Oste Matteo Biolatti Ari J. Salinger Santanu Mondal Paul R. Thompson Eranthie Weerapana Robert J. Lebbink Jasper A. Soppe Thomas Stamminger Virginie Girault Andreas Pichlmair Gábor Oroszlán Donald M. Coen Marco De Andrea Santo Landolfo |
| author_facet |
Gloria Griffante Francesca Gugliesi Selina Pasquero Valentina Dell’Oste Matteo Biolatti Ari J. Salinger Santanu Mondal Paul R. Thompson Eranthie Weerapana Robert J. Lebbink Jasper A. Soppe Thomas Stamminger Virginie Girault Andreas Pichlmair Gábor Oroszlán Donald M. Coen Marco De Andrea Santo Landolfo |
| author_sort |
Gloria Griffante |
| title |
Human cytomegalovirus-induced host protein citrullination is crucial for viral replication |
| title_short |
Human cytomegalovirus-induced host protein citrullination is crucial for viral replication |
| title_full |
Human cytomegalovirus-induced host protein citrullination is crucial for viral replication |
| title_fullStr |
Human cytomegalovirus-induced host protein citrullination is crucial for viral replication |
| title_full_unstemmed |
Human cytomegalovirus-induced host protein citrullination is crucial for viral replication |
| title_sort |
human cytomegalovirus-induced host protein citrullination is crucial for viral replication |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/d9f89f1cfaed42dc92c156e171d58d7e |
| work_keys_str_mv |
AT gloriagriffante humancytomegalovirusinducedhostproteincitrullinationiscrucialforviralreplication AT francescagugliesi humancytomegalovirusinducedhostproteincitrullinationiscrucialforviralreplication AT selinapasquero humancytomegalovirusinducedhostproteincitrullinationiscrucialforviralreplication AT valentinadelloste humancytomegalovirusinducedhostproteincitrullinationiscrucialforviralreplication AT matteobiolatti humancytomegalovirusinducedhostproteincitrullinationiscrucialforviralreplication AT arijsalinger humancytomegalovirusinducedhostproteincitrullinationiscrucialforviralreplication AT santanumondal humancytomegalovirusinducedhostproteincitrullinationiscrucialforviralreplication AT paulrthompson humancytomegalovirusinducedhostproteincitrullinationiscrucialforviralreplication AT eranthieweerapana humancytomegalovirusinducedhostproteincitrullinationiscrucialforviralreplication AT robertjlebbink humancytomegalovirusinducedhostproteincitrullinationiscrucialforviralreplication AT jasperasoppe humancytomegalovirusinducedhostproteincitrullinationiscrucialforviralreplication AT thomasstamminger humancytomegalovirusinducedhostproteincitrullinationiscrucialforviralreplication AT virginiegirault humancytomegalovirusinducedhostproteincitrullinationiscrucialforviralreplication AT andreaspichlmair humancytomegalovirusinducedhostproteincitrullinationiscrucialforviralreplication AT gabororoszlan humancytomegalovirusinducedhostproteincitrullinationiscrucialforviralreplication AT donaldmcoen humancytomegalovirusinducedhostproteincitrullinationiscrucialforviralreplication AT marcodeandrea humancytomegalovirusinducedhostproteincitrullinationiscrucialforviralreplication AT santolandolfo humancytomegalovirusinducedhostproteincitrullinationiscrucialforviralreplication |
| _version_ |
1718381350071828480 |