Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist

Mobilizing haematopoietic stem cells to the peripheral blood has largely replaced bone marrow transplants as a strategy in the clinic. Here, Cao et al. report the use of an α9β1/α4β1integrin antagonist to induce rapid mobilization of blood stem cells from the bone marrow in a humanized mouse model....

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Autores principales: Benjamin Cao, Zhen Zhang, Jochen Grassinger, Brenda Williams, Chad K. Heazlewood, Quentin I. Churches, Simon A. James, Songhui Li, Thalia Papayannopoulou, Susan K. Nilsson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/da0cd1920a214e60a77818aaf0b365f2
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