Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist

Mobilizing haematopoietic stem cells to the peripheral blood has largely replaced bone marrow transplants as a strategy in the clinic. Here, Cao et al. report the use of an α9β1/α4β1integrin antagonist to induce rapid mobilization of blood stem cells from the bone marrow in a humanized mouse model....

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Autores principales:	Benjamin Cao, Zhen Zhang, Jochen Grassinger, Brenda Williams, Chad K. Heazlewood, Quentin I. Churches, Simon A. James, Songhui Li, Thalia Papayannopoulou, Susan K. Nilsson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/da0cd1920a214e60a77818aaf0b365f2
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spelling	oai:doaj.org-article:da0cd1920a214e60a77818aaf0b365f22021-12-02T16:56:45ZTherapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist10.1038/ncomms110072041-1723https://doaj.org/article/da0cd1920a214e60a77818aaf0b365f22016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms11007https://doaj.org/toc/2041-1723Mobilizing haematopoietic stem cells to the peripheral blood has largely replaced bone marrow transplants as a strategy in the clinic. Here, Cao et al. report the use of an α9β1/α4β1integrin antagonist to induce rapid mobilization of blood stem cells from the bone marrow in a humanized mouse model.Benjamin CaoZhen ZhangJochen GrassingerBrenda WilliamsChad K. HeazlewoodQuentin I. ChurchesSimon A. JamesSonghui LiThalia PapayannopoulouSusan K. NilssonNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Benjamin Cao Zhen Zhang Jochen Grassinger Brenda Williams Chad K. Heazlewood Quentin I. Churches Simon A. James Songhui Li Thalia Papayannopoulou Susan K. Nilsson Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist
description	Mobilizing haematopoietic stem cells to the peripheral blood has largely replaced bone marrow transplants as a strategy in the clinic. Here, Cao et al. report the use of an α9β1/α4β1integrin antagonist to induce rapid mobilization of blood stem cells from the bone marrow in a humanized mouse model.
format	article
author	Benjamin Cao Zhen Zhang Jochen Grassinger Brenda Williams Chad K. Heazlewood Quentin I. Churches Simon A. James Songhui Li Thalia Papayannopoulou Susan K. Nilsson
author_facet	Benjamin Cao Zhen Zhang Jochen Grassinger Brenda Williams Chad K. Heazlewood Quentin I. Churches Simon A. James Songhui Li Thalia Papayannopoulou Susan K. Nilsson
author_sort	Benjamin Cao
title	Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist
title_short	Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist
title_full	Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist
title_fullStr	Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist
title_full_unstemmed	Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist
title_sort	therapeutic targeting and rapid mobilization of endosteal hsc using a small molecule integrin antagonist
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/da0cd1920a214e60a77818aaf0b365f2
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Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist

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