DNA translocation mechanism of the MCM complex and implications for replication initiation

Eukaryotes and archaea use a heximeric ring-shaped MCM helicase to unwind the DNA template during replication. Here the authors present a crystal structure of the MCM complex from archaeon S. solfataricus bound to single-stranded DNA, and to a combination of ADP, and ATP-mimic, ADP-BeF3.

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Autores principales:	Martin Meagher, Leslie B. Epling, Eric J. Enemark
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/da3d2f86275a48fca8e4523d176c6988
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spelling	oai:doaj.org-article:da3d2f86275a48fca8e4523d176c69882021-12-02T15:35:31ZDNA translocation mechanism of the MCM complex and implications for replication initiation10.1038/s41467-019-11074-32041-1723https://doaj.org/article/da3d2f86275a48fca8e4523d176c69882019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11074-3https://doaj.org/toc/2041-1723Eukaryotes and archaea use a heximeric ring-shaped MCM helicase to unwind the DNA template during replication. Here the authors present a crystal structure of the MCM complex from archaeon S. solfataricus bound to single-stranded DNA, and to a combination of ADP, and ATP-mimic, ADP-BeF3.Martin MeagherLeslie B. EplingEric J. EnemarkNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Martin Meagher Leslie B. Epling Eric J. Enemark DNA translocation mechanism of the MCM complex and implications for replication initiation
description	Eukaryotes and archaea use a heximeric ring-shaped MCM helicase to unwind the DNA template during replication. Here the authors present a crystal structure of the MCM complex from archaeon S. solfataricus bound to single-stranded DNA, and to a combination of ADP, and ATP-mimic, ADP-BeF3.
format	article
author	Martin Meagher Leslie B. Epling Eric J. Enemark
author_facet	Martin Meagher Leslie B. Epling Eric J. Enemark
author_sort	Martin Meagher
title	DNA translocation mechanism of the MCM complex and implications for replication initiation
title_short	DNA translocation mechanism of the MCM complex and implications for replication initiation
title_full	DNA translocation mechanism of the MCM complex and implications for replication initiation
title_fullStr	DNA translocation mechanism of the MCM complex and implications for replication initiation
title_full_unstemmed	DNA translocation mechanism of the MCM complex and implications for replication initiation
title_sort	dna translocation mechanism of the mcm complex and implications for replication initiation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/da3d2f86275a48fca8e4523d176c6988
work_keys_str_mv	AT martinmeagher dnatranslocationmechanismofthemcmcomplexandimplicationsforreplicationinitiation AT lesliebepling dnatranslocationmechanismofthemcmcomplexandimplicationsforreplicationinitiation AT ericjenemark dnatranslocationmechanismofthemcmcomplexandimplicationsforreplicationinitiation
_version_	1718386564639227904

DNA translocation mechanism of the MCM complex and implications for replication initiation

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