Single-mutation fitness landscapes for an enzyme on multiple substrates reveal specificity is globally encoded

Systematically understanding the sequence determinants to substrate specificity for enzymes has implications in areas from evolutionary biology to biocatalysis. Here, Whitehead and colleagues generate and analyse near-comprehensive single-mutation fitness landscapes for an amidase with three differe...

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Autores principales: Emily E. Wrenbeck, Laura R. Azouz, Timothy A. Whitehead
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/da48e47ebe3f4c798a64a10a429756a4
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