Single-mutation fitness landscapes for an enzyme on multiple substrates reveal specificity is globally encoded

Systematically understanding the sequence determinants to substrate specificity for enzymes has implications in areas from evolutionary biology to biocatalysis. Here, Whitehead and colleagues generate and analyse near-comprehensive single-mutation fitness landscapes for an amidase with three differe...

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Autores principales:	Emily E. Wrenbeck, Laura R. Azouz, Timothy A. Whitehead
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/da48e47ebe3f4c798a64a10a429756a4
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spelling	oai:doaj.org-article:da48e47ebe3f4c798a64a10a429756a42021-12-02T14:40:50ZSingle-mutation fitness landscapes for an enzyme on multiple substrates reveal specificity is globally encoded10.1038/ncomms156952041-1723https://doaj.org/article/da48e47ebe3f4c798a64a10a429756a42017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15695https://doaj.org/toc/2041-1723Systematically understanding the sequence determinants to substrate specificity for enzymes has implications in areas from evolutionary biology to biocatalysis. Here, Whitehead and colleagues generate and analyse near-comprehensive single-mutation fitness landscapes for an amidase with three different substrates.Emily E. WrenbeckLaura R. AzouzTimothy A. WhiteheadNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Emily E. Wrenbeck Laura R. Azouz Timothy A. Whitehead Single-mutation fitness landscapes for an enzyme on multiple substrates reveal specificity is globally encoded
description	Systematically understanding the sequence determinants to substrate specificity for enzymes has implications in areas from evolutionary biology to biocatalysis. Here, Whitehead and colleagues generate and analyse near-comprehensive single-mutation fitness landscapes for an amidase with three different substrates.
format	article
author	Emily E. Wrenbeck Laura R. Azouz Timothy A. Whitehead
author_facet	Emily E. Wrenbeck Laura R. Azouz Timothy A. Whitehead
author_sort	Emily E. Wrenbeck
title	Single-mutation fitness landscapes for an enzyme on multiple substrates reveal specificity is globally encoded
title_short	Single-mutation fitness landscapes for an enzyme on multiple substrates reveal specificity is globally encoded
title_full	Single-mutation fitness landscapes for an enzyme on multiple substrates reveal specificity is globally encoded
title_fullStr	Single-mutation fitness landscapes for an enzyme on multiple substrates reveal specificity is globally encoded
title_full_unstemmed	Single-mutation fitness landscapes for an enzyme on multiple substrates reveal specificity is globally encoded
title_sort	single-mutation fitness landscapes for an enzyme on multiple substrates reveal specificity is globally encoded
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/da48e47ebe3f4c798a64a10a429756a4
work_keys_str_mv	AT emilyewrenbeck singlemutationfitnesslandscapesforanenzymeonmultiplesubstratesrevealspecificityisgloballyencoded AT laurarazouz singlemutationfitnesslandscapesforanenzymeonmultiplesubstratesrevealspecificityisgloballyencoded AT timothyawhitehead singlemutationfitnesslandscapesforanenzymeonmultiplesubstratesrevealspecificityisgloballyencoded
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Single-mutation fitness landscapes for an enzyme on multiple substrates reveal specificity is globally encoded

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