Resolution of tissue signatures of therapy response in patients with recurrent GBM treated with neoadjuvant anti-PD1

The response to neoadjuvant immune checkpoint blockade (ICB) in patients with recurrent gliolastoma multiforme (GBM) has been challenging to interpret. Here the authors develop a tumor analysis framework that reveals molecular similarities between GBM and melanoma and unique patterns of immunosuppre...

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Autores principales:	Yue Lu, Alphonsus H. C. Ng, Frances E. Chow, Richard G. Everson, Beth A. Helmink, Michael T. Tetzlaff, Rohit Thakur, Jennifer A. Wargo, Timothy F. Cloughesy, Robert M. Prins, James R. Heath
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/da58c67153ba43c0bfe64ab0eaad9f67
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spelling	oai:doaj.org-article:da58c67153ba43c0bfe64ab0eaad9f672021-12-02T16:10:47ZResolution of tissue signatures of therapy response in patients with recurrent GBM treated with neoadjuvant anti-PD110.1038/s41467-021-24293-42041-1723https://doaj.org/article/da58c67153ba43c0bfe64ab0eaad9f672021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24293-4https://doaj.org/toc/2041-1723The response to neoadjuvant immune checkpoint blockade (ICB) in patients with recurrent gliolastoma multiforme (GBM) has been challenging to interpret. Here the authors develop a tumor analysis framework that reveals molecular similarities between GBM and melanoma and unique patterns of immunosuppression in GBM indicating potential co-targets for neoadjuvant ICB.Yue LuAlphonsus H. C. NgFrances E. ChowRichard G. EversonBeth A. HelminkMichael T. TetzlaffRohit ThakurJennifer A. WargoTimothy F. CloughesyRobert M. PrinsJames R. HeathNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yue Lu Alphonsus H. C. Ng Frances E. Chow Richard G. Everson Beth A. Helmink Michael T. Tetzlaff Rohit Thakur Jennifer A. Wargo Timothy F. Cloughesy Robert M. Prins James R. Heath Resolution of tissue signatures of therapy response in patients with recurrent GBM treated with neoadjuvant anti-PD1
description	The response to neoadjuvant immune checkpoint blockade (ICB) in patients with recurrent gliolastoma multiforme (GBM) has been challenging to interpret. Here the authors develop a tumor analysis framework that reveals molecular similarities between GBM and melanoma and unique patterns of immunosuppression in GBM indicating potential co-targets for neoadjuvant ICB.
format	article
author	Yue Lu Alphonsus H. C. Ng Frances E. Chow Richard G. Everson Beth A. Helmink Michael T. Tetzlaff Rohit Thakur Jennifer A. Wargo Timothy F. Cloughesy Robert M. Prins James R. Heath
author_facet	Yue Lu Alphonsus H. C. Ng Frances E. Chow Richard G. Everson Beth A. Helmink Michael T. Tetzlaff Rohit Thakur Jennifer A. Wargo Timothy F. Cloughesy Robert M. Prins James R. Heath
author_sort	Yue Lu
title	Resolution of tissue signatures of therapy response in patients with recurrent GBM treated with neoadjuvant anti-PD1
title_short	Resolution of tissue signatures of therapy response in patients with recurrent GBM treated with neoadjuvant anti-PD1
title_full	Resolution of tissue signatures of therapy response in patients with recurrent GBM treated with neoadjuvant anti-PD1
title_fullStr	Resolution of tissue signatures of therapy response in patients with recurrent GBM treated with neoadjuvant anti-PD1
title_full_unstemmed	Resolution of tissue signatures of therapy response in patients with recurrent GBM treated with neoadjuvant anti-PD1
title_sort	resolution of tissue signatures of therapy response in patients with recurrent gbm treated with neoadjuvant anti-pd1
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/da58c67153ba43c0bfe64ab0eaad9f67
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Resolution of tissue signatures of therapy response in patients with recurrent GBM treated with neoadjuvant anti-PD1

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