Vaccination with Adjuvanted Recombinant Neuraminidase Induces Broad Heterologous, but Not Heterosubtypic, Cross-Protection against Influenza Virus Infection in Mice

ABSTRACT In an attempt to assess the cross-protective potential of the influenza virus neuraminidase (NA) as a vaccine antigen, different subtypes of recombinant NA were expressed in a baculovirus system and used to vaccinate mice prior to lethal challenge with homologous, heterologous, or heterosub...

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Bibliographic Details
Main Authors: Teddy John Wohlbold, Raffael Nachbagauer, Haoming Xu, Gene S. Tan, Ariana Hirsh, Karl A. Brokstad, Rebecca J. Cox, Peter Palese, Florian Krammer
Format: article
Language:EN
Published: American Society for Microbiology 2015
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Online Access:https://doaj.org/article/da8a80e009fe433e962da33989dcbe5a
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