Loss of testosterone impairs anti-tumor neutrophil function

It is known that there are sex differences in the incidence and prognosis of certain cancers, including melanoma. In this study, the authors utilize a melanoma model to reveal that castrated mice have a higher metastatic burden associated with androgen dependent impaired neutrophil function.

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Autores principales: Janet L. Markman, Rebecca A. Porritt, Daiko Wakita, Malcolm E. Lane, Daisy Martinon, Magali Noval Rivas, Michael Luu, Edwin M. Posadas, Timothy R. Crother, Moshe Arditi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/da94dd5ff86540ef8cf0216912c0ab16
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