Loss of testosterone impairs anti-tumor neutrophil function

It is known that there are sex differences in the incidence and prognosis of certain cancers, including melanoma. In this study, the authors utilize a melanoma model to reveal that castrated mice have a higher metastatic burden associated with androgen dependent impaired neutrophil function.

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Autores principales:	Janet L. Markman, Rebecca A. Porritt, Daiko Wakita, Malcolm E. Lane, Daisy Martinon, Magali Noval Rivas, Michael Luu, Edwin M. Posadas, Timothy R. Crother, Moshe Arditi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/da94dd5ff86540ef8cf0216912c0ab16
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spelling	oai:doaj.org-article:da94dd5ff86540ef8cf0216912c0ab162021-12-02T15:39:07ZLoss of testosterone impairs anti-tumor neutrophil function10.1038/s41467-020-15397-42041-1723https://doaj.org/article/da94dd5ff86540ef8cf0216912c0ab162020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15397-4https://doaj.org/toc/2041-1723It is known that there are sex differences in the incidence and prognosis of certain cancers, including melanoma. In this study, the authors utilize a melanoma model to reveal that castrated mice have a higher metastatic burden associated with androgen dependent impaired neutrophil function.Janet L. MarkmanRebecca A. PorrittDaiko WakitaMalcolm E. LaneDaisy MartinonMagali Noval RivasMichael LuuEdwin M. PosadasTimothy R. CrotherMoshe ArditiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Janet L. Markman Rebecca A. Porritt Daiko Wakita Malcolm E. Lane Daisy Martinon Magali Noval Rivas Michael Luu Edwin M. Posadas Timothy R. Crother Moshe Arditi Loss of testosterone impairs anti-tumor neutrophil function
description	It is known that there are sex differences in the incidence and prognosis of certain cancers, including melanoma. In this study, the authors utilize a melanoma model to reveal that castrated mice have a higher metastatic burden associated with androgen dependent impaired neutrophil function.
format	article
author	Janet L. Markman Rebecca A. Porritt Daiko Wakita Malcolm E. Lane Daisy Martinon Magali Noval Rivas Michael Luu Edwin M. Posadas Timothy R. Crother Moshe Arditi
author_facet	Janet L. Markman Rebecca A. Porritt Daiko Wakita Malcolm E. Lane Daisy Martinon Magali Noval Rivas Michael Luu Edwin M. Posadas Timothy R. Crother Moshe Arditi
author_sort	Janet L. Markman
title	Loss of testosterone impairs anti-tumor neutrophil function
title_short	Loss of testosterone impairs anti-tumor neutrophil function
title_full	Loss of testosterone impairs anti-tumor neutrophil function
title_fullStr	Loss of testosterone impairs anti-tumor neutrophil function
title_full_unstemmed	Loss of testosterone impairs anti-tumor neutrophil function
title_sort	loss of testosterone impairs anti-tumor neutrophil function
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/da94dd5ff86540ef8cf0216912c0ab16
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Loss of testosterone impairs anti-tumor neutrophil function

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