BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models

Preventing phosphorylation of BAD (3SA) in mouse models and human cells inhibits mammary gland development, acting by disrupting 4E-BP1- mediated translation and affecting focal adhesion/protrusion stability, cell migration and ductal tubulogenesis.

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Autores principales:	John Maringa Githaka, Namita Tripathi, Raven Kirschenman, Namrata Patel, Vrajesh Pandya, David A. Kramer, Rachel Montpetit, Lin Fu Zhu, Nahum Sonenberg, Richard P. Fahlman, Nika N. Danial, D. Alan Underhill, Ing Swie Goping
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/da9677ace6fa4ee0a7b417531c2a2ab1
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spelling	oai:doaj.org-article:da9677ace6fa4ee0a7b417531c2a2ab12021-12-02T15:45:30ZBAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models10.1038/s41467-021-23269-82041-1723https://doaj.org/article/da9677ace6fa4ee0a7b417531c2a2ab12021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23269-8https://doaj.org/toc/2041-1723Preventing phosphorylation of BAD (3SA) in mouse models and human cells inhibits mammary gland development, acting by disrupting 4E-BP1- mediated translation and affecting focal adhesion/protrusion stability, cell migration and ductal tubulogenesis.John Maringa GithakaNamita TripathiRaven KirschenmanNamrata PatelVrajesh PandyaDavid A. KramerRachel MontpetitLin Fu ZhuNahum SonenbergRichard P. FahlmanNika N. DanialD. Alan UnderhillIng Swie GopingNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q John Maringa Githaka Namita Tripathi Raven Kirschenman Namrata Patel Vrajesh Pandya David A. Kramer Rachel Montpetit Lin Fu Zhu Nahum Sonenberg Richard P. Fahlman Nika N. Danial D. Alan Underhill Ing Swie Goping BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models
description	Preventing phosphorylation of BAD (3SA) in mouse models and human cells inhibits mammary gland development, acting by disrupting 4E-BP1- mediated translation and affecting focal adhesion/protrusion stability, cell migration and ductal tubulogenesis.
format	article
author	John Maringa Githaka Namita Tripathi Raven Kirschenman Namrata Patel Vrajesh Pandya David A. Kramer Rachel Montpetit Lin Fu Zhu Nahum Sonenberg Richard P. Fahlman Nika N. Danial D. Alan Underhill Ing Swie Goping
author_facet	John Maringa Githaka Namita Tripathi Raven Kirschenman Namrata Patel Vrajesh Pandya David A. Kramer Rachel Montpetit Lin Fu Zhu Nahum Sonenberg Richard P. Fahlman Nika N. Danial D. Alan Underhill Ing Swie Goping
author_sort	John Maringa Githaka
title	BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models
title_short	BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models
title_full	BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models
title_fullStr	BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models
title_full_unstemmed	BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models
title_sort	bad regulates mammary gland morphogenesis by 4e-bp1-mediated control of localized translation in mouse and human models
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/da9677ace6fa4ee0a7b417531c2a2ab1
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BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models

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