Microglial dopamine receptor elimination defines sex-specific nucleus accumbens development and social behavior in adolescent rats

Dopaminergic circuits in the nucleus accumbens regulate reward, including social play behavior in adolescent rodents. Here, the authors show that in male but not female rats, dopamine receptors are tagged by complement for microglial phagocytosis, thus mediating changes in social behavior.

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Autores principales:	Ashley M. Kopec, Caroline J. Smith, Nathan R. Ayre, Sean C. Sweat, Staci D. Bilbo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dadd63e2136e48ce8dc7b2c0ad514588
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spelling	oai:doaj.org-article:dadd63e2136e48ce8dc7b2c0ad5145882021-12-02T14:39:10ZMicroglial dopamine receptor elimination defines sex-specific nucleus accumbens development and social behavior in adolescent rats10.1038/s41467-018-06118-z2041-1723https://doaj.org/article/dadd63e2136e48ce8dc7b2c0ad5145882018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06118-zhttps://doaj.org/toc/2041-1723Dopaminergic circuits in the nucleus accumbens regulate reward, including social play behavior in adolescent rodents. Here, the authors show that in male but not female rats, dopamine receptors are tagged by complement for microglial phagocytosis, thus mediating changes in social behavior.Ashley M. KopecCaroline J. SmithNathan R. AyreSean C. SweatStaci D. BilboNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ashley M. Kopec Caroline J. Smith Nathan R. Ayre Sean C. Sweat Staci D. Bilbo Microglial dopamine receptor elimination defines sex-specific nucleus accumbens development and social behavior in adolescent rats
description	Dopaminergic circuits in the nucleus accumbens regulate reward, including social play behavior in adolescent rodents. Here, the authors show that in male but not female rats, dopamine receptors are tagged by complement for microglial phagocytosis, thus mediating changes in social behavior.
format	article
author	Ashley M. Kopec Caroline J. Smith Nathan R. Ayre Sean C. Sweat Staci D. Bilbo
author_facet	Ashley M. Kopec Caroline J. Smith Nathan R. Ayre Sean C. Sweat Staci D. Bilbo
author_sort	Ashley M. Kopec
title	Microglial dopamine receptor elimination defines sex-specific nucleus accumbens development and social behavior in adolescent rats
title_short	Microglial dopamine receptor elimination defines sex-specific nucleus accumbens development and social behavior in adolescent rats
title_full	Microglial dopamine receptor elimination defines sex-specific nucleus accumbens development and social behavior in adolescent rats
title_fullStr	Microglial dopamine receptor elimination defines sex-specific nucleus accumbens development and social behavior in adolescent rats
title_full_unstemmed	Microglial dopamine receptor elimination defines sex-specific nucleus accumbens development and social behavior in adolescent rats
title_sort	microglial dopamine receptor elimination defines sex-specific nucleus accumbens development and social behavior in adolescent rats
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/dadd63e2136e48ce8dc7b2c0ad514588
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Microglial dopamine receptor elimination defines sex-specific nucleus accumbens development and social behavior in adolescent rats

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