Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection

Mitotic catastrophe is a regulated mechanism that responds to aberrant mitoses leading to removal of damaged cells. Here the authors reveal how replication stress induces mitotic death through pathways regulated by WAPL and telomere deprotection.

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Autores principales:	V. Pragathi Masamsetti, Ronnie Ren Jie Low, Ka Sin Mak, Aisling O’Connor, Chris D. Riffkin, Noa Lamm, Laure Crabbe, Jan Karlseder, David C. S. Huang, Makoto T. Hayashi, Anthony J. Cesare
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dae63874a0924b7f84dd69ccfd135eb0
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spelling	oai:doaj.org-article:dae63874a0924b7f84dd69ccfd135eb02021-12-02T17:02:08ZReplication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection10.1038/s41467-019-12255-w2041-1723https://doaj.org/article/dae63874a0924b7f84dd69ccfd135eb02019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12255-whttps://doaj.org/toc/2041-1723Mitotic catastrophe is a regulated mechanism that responds to aberrant mitoses leading to removal of damaged cells. Here the authors reveal how replication stress induces mitotic death through pathways regulated by WAPL and telomere deprotection.V. Pragathi MasamsettiRonnie Ren Jie LowKa Sin MakAisling O’ConnorChris D. RiffkinNoa LammLaure CrabbeJan KarlsederDavid C. S. HuangMakoto T. HayashiAnthony J. CesareNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q V. Pragathi Masamsetti Ronnie Ren Jie Low Ka Sin Mak Aisling O’Connor Chris D. Riffkin Noa Lamm Laure Crabbe Jan Karlseder David C. S. Huang Makoto T. Hayashi Anthony J. Cesare Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection
description	Mitotic catastrophe is a regulated mechanism that responds to aberrant mitoses leading to removal of damaged cells. Here the authors reveal how replication stress induces mitotic death through pathways regulated by WAPL and telomere deprotection.
format	article
author	V. Pragathi Masamsetti Ronnie Ren Jie Low Ka Sin Mak Aisling O’Connor Chris D. Riffkin Noa Lamm Laure Crabbe Jan Karlseder David C. S. Huang Makoto T. Hayashi Anthony J. Cesare
author_facet	V. Pragathi Masamsetti Ronnie Ren Jie Low Ka Sin Mak Aisling O’Connor Chris D. Riffkin Noa Lamm Laure Crabbe Jan Karlseder David C. S. Huang Makoto T. Hayashi Anthony J. Cesare
author_sort	V. Pragathi Masamsetti
title	Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection
title_short	Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection
title_full	Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection
title_fullStr	Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection
title_full_unstemmed	Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection
title_sort	replication stress induces mitotic death through parallel pathways regulated by wapl and telomere deprotection
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/dae63874a0924b7f84dd69ccfd135eb0
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Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection

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