Off-the-shelf proximity biotinylation for interaction proteomics

Proximity biotinylation is a powerful tool to profile interactomes, but it requires genetic engineering of the target protein. Here, the authors develop a proximity biotinylation enzyme that can be directed to the target using antibodies, enabling interactome profiling of endogenous proteins or PTMs...

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Bibliographic Details
Main Authors: Irene Santos-Barriopedro, Guido van Mierlo, Michiel Vermeulen
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
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Online Access:https://doaj.org/article/daee1039e77c42bc92b128ce138c9f8d
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