Nanoscale metal-organic frameworks enhance radiotherapy to potentiate checkpoint blockade immunotherapy

Radiotherapy is known to have local immunomodulatory effects, while an effective systemic immune response is an issue. Here, the authors report on nMOF radiosensitizers for enhanced radiotherapy which in combination with anti-PD-L1 antibodies result in a systemic immune response to distant tumors.

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Autores principales:	Kaiyuan Ni, Guangxu Lan, Christina Chan, Bryan Quigley, Kuangda Lu, Theint Aung, Nining Guo, Patrick La Riviere, Ralph R. Weichselbaum, Wenbin Lin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/db41bef7778549148a55e90f5c3092eb
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spelling	oai:doaj.org-article:db41bef7778549148a55e90f5c3092eb2021-12-02T17:32:32ZNanoscale metal-organic frameworks enhance radiotherapy to potentiate checkpoint blockade immunotherapy10.1038/s41467-018-04703-w2041-1723https://doaj.org/article/db41bef7778549148a55e90f5c3092eb2018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04703-whttps://doaj.org/toc/2041-1723Radiotherapy is known to have local immunomodulatory effects, while an effective systemic immune response is an issue. Here, the authors report on nMOF radiosensitizers for enhanced radiotherapy which in combination with anti-PD-L1 antibodies result in a systemic immune response to distant tumors.Kaiyuan NiGuangxu LanChristina ChanBryan QuigleyKuangda LuTheint AungNining GuoPatrick La RiviereRalph R. WeichselbaumWenbin LinNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kaiyuan Ni Guangxu Lan Christina Chan Bryan Quigley Kuangda Lu Theint Aung Nining Guo Patrick La Riviere Ralph R. Weichselbaum Wenbin Lin Nanoscale metal-organic frameworks enhance radiotherapy to potentiate checkpoint blockade immunotherapy
description	Radiotherapy is known to have local immunomodulatory effects, while an effective systemic immune response is an issue. Here, the authors report on nMOF radiosensitizers for enhanced radiotherapy which in combination with anti-PD-L1 antibodies result in a systemic immune response to distant tumors.
format	article
author	Kaiyuan Ni Guangxu Lan Christina Chan Bryan Quigley Kuangda Lu Theint Aung Nining Guo Patrick La Riviere Ralph R. Weichselbaum Wenbin Lin
author_facet	Kaiyuan Ni Guangxu Lan Christina Chan Bryan Quigley Kuangda Lu Theint Aung Nining Guo Patrick La Riviere Ralph R. Weichselbaum Wenbin Lin
author_sort	Kaiyuan Ni
title	Nanoscale metal-organic frameworks enhance radiotherapy to potentiate checkpoint blockade immunotherapy
title_short	Nanoscale metal-organic frameworks enhance radiotherapy to potentiate checkpoint blockade immunotherapy
title_full	Nanoscale metal-organic frameworks enhance radiotherapy to potentiate checkpoint blockade immunotherapy
title_fullStr	Nanoscale metal-organic frameworks enhance radiotherapy to potentiate checkpoint blockade immunotherapy
title_full_unstemmed	Nanoscale metal-organic frameworks enhance radiotherapy to potentiate checkpoint blockade immunotherapy
title_sort	nanoscale metal-organic frameworks enhance radiotherapy to potentiate checkpoint blockade immunotherapy
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/db41bef7778549148a55e90f5c3092eb
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Nanoscale metal-organic frameworks enhance radiotherapy to potentiate checkpoint blockade immunotherapy

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