Rebalancing of actomyosin contractility enables mammary tumor formation upon loss of E-cadherin

E-cadherin is a well-known tumor suppressor albeit loss of E-cadherin alone is insufficient to induce mammary tumorigenesis. Here the authors report that epithelial cells that have lost E-cadherin can survive by extruding to the basal lamina but require rebalancing of actomyosin contractility to dri...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Koen Schipper, Danielle Seinstra, Anne Paulien Drenth, Eline van der Burg, Veronika Ramovs, Arnoud Sonnenberg, Jacco van Rheenen, Micha Nethe, Jos Jonkers
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/db63cd2a463f498782159daf9e40c722
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:db63cd2a463f498782159daf9e40c722
record_format	dspace
spelling	oai:doaj.org-article:db63cd2a463f498782159daf9e40c7222021-12-02T15:35:54ZRebalancing of actomyosin contractility enables mammary tumor formation upon loss of E-cadherin10.1038/s41467-019-11716-62041-1723https://doaj.org/article/db63cd2a463f498782159daf9e40c7222019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11716-6https://doaj.org/toc/2041-1723E-cadherin is a well-known tumor suppressor albeit loss of E-cadherin alone is insufficient to induce mammary tumorigenesis. Here the authors report that epithelial cells that have lost E-cadherin can survive by extruding to the basal lamina but require rebalancing of actomyosin contractility to drive tumor development.Koen SchipperDanielle SeinstraAnne Paulien DrenthEline van der BurgVeronika RamovsArnoud SonnenbergJacco van RheenenMicha NetheJos JonkersNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Koen Schipper Danielle Seinstra Anne Paulien Drenth Eline van der Burg Veronika Ramovs Arnoud Sonnenberg Jacco van Rheenen Micha Nethe Jos Jonkers Rebalancing of actomyosin contractility enables mammary tumor formation upon loss of E-cadherin
description	E-cadherin is a well-known tumor suppressor albeit loss of E-cadherin alone is insufficient to induce mammary tumorigenesis. Here the authors report that epithelial cells that have lost E-cadherin can survive by extruding to the basal lamina but require rebalancing of actomyosin contractility to drive tumor development.
format	article
author	Koen Schipper Danielle Seinstra Anne Paulien Drenth Eline van der Burg Veronika Ramovs Arnoud Sonnenberg Jacco van Rheenen Micha Nethe Jos Jonkers
author_facet	Koen Schipper Danielle Seinstra Anne Paulien Drenth Eline van der Burg Veronika Ramovs Arnoud Sonnenberg Jacco van Rheenen Micha Nethe Jos Jonkers
author_sort	Koen Schipper
title	Rebalancing of actomyosin contractility enables mammary tumor formation upon loss of E-cadherin
title_short	Rebalancing of actomyosin contractility enables mammary tumor formation upon loss of E-cadherin
title_full	Rebalancing of actomyosin contractility enables mammary tumor formation upon loss of E-cadherin
title_fullStr	Rebalancing of actomyosin contractility enables mammary tumor formation upon loss of E-cadherin
title_full_unstemmed	Rebalancing of actomyosin contractility enables mammary tumor formation upon loss of E-cadherin
title_sort	rebalancing of actomyosin contractility enables mammary tumor formation upon loss of e-cadherin
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/db63cd2a463f498782159daf9e40c722
work_keys_str_mv	AT koenschipper rebalancingofactomyosincontractilityenablesmammarytumorformationuponlossofecadherin AT danielleseinstra rebalancingofactomyosincontractilityenablesmammarytumorformationuponlossofecadherin AT annepauliendrenth rebalancingofactomyosincontractilityenablesmammarytumorformationuponlossofecadherin AT elinevanderburg rebalancingofactomyosincontractilityenablesmammarytumorformationuponlossofecadherin AT veronikaramovs rebalancingofactomyosincontractilityenablesmammarytumorformationuponlossofecadherin AT arnoudsonnenberg rebalancingofactomyosincontractilityenablesmammarytumorformationuponlossofecadherin AT jaccovanrheenen rebalancingofactomyosincontractilityenablesmammarytumorformationuponlossofecadherin AT michanethe rebalancingofactomyosincontractilityenablesmammarytumorformationuponlossofecadherin AT josjonkers rebalancingofactomyosincontractilityenablesmammarytumorformationuponlossofecadherin
_version_	1718386444029919232

Rebalancing of actomyosin contractility enables mammary tumor formation upon loss of E-cadherin

Ejemplares similares