Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators

Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators

Whether there are conserved nucleic acid (NA) binding proteins across species is not fully known. Using data from human, mouse and fly, the authors identify common binders, implicate TAOKs and show that these kinases bind NAs across species and promote virus defence in mammalian cells.

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Detalles Bibliográficos
Autores principales: Friederike L. Pennemann, Assel Mussabekova, Christian Urban, Alexey Stukalov, Line Lykke Andersen, Vincent Grass, Teresa Maria Lavacca, Cathleen Holze, Lila Oubraham, Yasmine Benamrouche, Enrico Girardi, Rasha E. Boulos, Rune Hartmann, Giulio Superti-Furga, Matthias Habjan, Jean-Luc Imler, Carine Meignin, Andreas Pichlmair
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
Q
Acceso en línea:https://doaj.org/article/db868955f145422faefd0ca10f89353c
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Descripción
Sumario:Whether there are conserved nucleic acid (NA) binding proteins across species is not fully known. Using data from human, mouse and fly, the authors identify common binders, implicate TAOKs and show that these kinases bind NAs across species and promote virus defence in mammalian cells.

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