Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators

Whether there are conserved nucleic acid (NA) binding proteins across species is not fully known. Using data from human, mouse and fly, the authors identify common binders, implicate TAOKs and show that these kinases bind NAs across species and promote virus defence in mammalian cells.

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Autores principales:	Friederike L. Pennemann, Assel Mussabekova, Christian Urban, Alexey Stukalov, Line Lykke Andersen, Vincent Grass, Teresa Maria Lavacca, Cathleen Holze, Lila Oubraham, Yasmine Benamrouche, Enrico Girardi, Rasha E. Boulos, Rune Hartmann, Giulio Superti-Furga, Matthias Habjan, Jean-Luc Imler, Carine Meignin, Andreas Pichlmair
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/db868955f145422faefd0ca10f89353c
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spelling	oai:doaj.org-article:db868955f145422faefd0ca10f89353c2021-12-05T12:23:12ZCross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators10.1038/s41467-021-27192-w2041-1723https://doaj.org/article/db868955f145422faefd0ca10f89353c2021-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27192-whttps://doaj.org/toc/2041-1723Whether there are conserved nucleic acid (NA) binding proteins across species is not fully known. Using data from human, mouse and fly, the authors identify common binders, implicate TAOKs and show that these kinases bind NAs across species and promote virus defence in mammalian cells.Friederike L. PennemannAssel MussabekovaChristian UrbanAlexey StukalovLine Lykke AndersenVincent GrassTeresa Maria LavaccaCathleen HolzeLila OubrahamYasmine BenamroucheEnrico GirardiRasha E. BoulosRune HartmannGiulio Superti-FurgaMatthias HabjanJean-Luc ImlerCarine MeigninAndreas PichlmairNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Friederike L. Pennemann Assel Mussabekova Christian Urban Alexey Stukalov Line Lykke Andersen Vincent Grass Teresa Maria Lavacca Cathleen Holze Lila Oubraham Yasmine Benamrouche Enrico Girardi Rasha E. Boulos Rune Hartmann Giulio Superti-Furga Matthias Habjan Jean-Luc Imler Carine Meignin Andreas Pichlmair Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators
description	Whether there are conserved nucleic acid (NA) binding proteins across species is not fully known. Using data from human, mouse and fly, the authors identify common binders, implicate TAOKs and show that these kinases bind NAs across species and promote virus defence in mammalian cells.
format	article
author	Friederike L. Pennemann Assel Mussabekova Christian Urban Alexey Stukalov Line Lykke Andersen Vincent Grass Teresa Maria Lavacca Cathleen Holze Lila Oubraham Yasmine Benamrouche Enrico Girardi Rasha E. Boulos Rune Hartmann Giulio Superti-Furga Matthias Habjan Jean-Luc Imler Carine Meignin Andreas Pichlmair
author_facet	Friederike L. Pennemann Assel Mussabekova Christian Urban Alexey Stukalov Line Lykke Andersen Vincent Grass Teresa Maria Lavacca Cathleen Holze Lila Oubraham Yasmine Benamrouche Enrico Girardi Rasha E. Boulos Rune Hartmann Giulio Superti-Furga Matthias Habjan Jean-Luc Imler Carine Meignin Andreas Pichlmair
author_sort	Friederike L. Pennemann
title	Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators
title_short	Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators
title_full	Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators
title_fullStr	Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators
title_full_unstemmed	Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators
title_sort	cross-species analysis of viral nucleic acid interacting proteins identifies taoks as innate immune regulators
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/db868955f145422faefd0ca10f89353c
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Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators

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