Rational extension of the ribosome biogenesis pathway using network-guided genetics.

Biogenesis of ribosomes is an essential cellular process conserved across all eukaryotes and is known to require >170 genes for the assembly, modification, and trafficking of ribosome components through multiple cellular compartments. Despite intensive study, this pathway likely involves many add...

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Bibliographic Details
Main Authors: Zhihua Li, Insuk Lee, Emily Moradi, Nai-Jung Hung, Arlen W Johnson, Edward M Marcotte
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2009
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Online Access:https://doaj.org/article/dba530d8aa634d3295d41a9626dbda62
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