CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s disease
CLR01 is a molecular tweezer that inhibits protein aggregation. Here the authors show that CLR01 protects dopaminergic neurons in vitro and in vivo in human neurons and in mouse models showing potential as a disease-modifying therapy for Parkinson’s disease.
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Nature Portfolio
2020
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| Acceso en línea: | https://doaj.org/article/dbb405cbb99f4bdb826102e5b534b7da |
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oai:doaj.org-article:dbb405cbb99f4bdb826102e5b534b7da2021-12-02T17:18:08ZCLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s disease10.1038/s41467-020-18689-x2041-1723https://doaj.org/article/dbb405cbb99f4bdb826102e5b534b7da2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18689-xhttps://doaj.org/toc/2041-1723CLR01 is a molecular tweezer that inhibits protein aggregation. Here the authors show that CLR01 protects dopaminergic neurons in vitro and in vivo in human neurons and in mouse models showing potential as a disease-modifying therapy for Parkinson’s disease.Nora Bengoa-VergnioryEmilie FaggianiPaula Ramos-GonzalezEcem KirkizNatalie Connor-RobsonLiam V. BrownIbrar SiddiqueZizheng LiSiv VingillMilena CiorochFabio CavaliereSarah ThrelfellBradley RobertsThomas SchraderFrank-Gerrit KlärnerStephanie CraggBenjamin DehayGal BitanCarlos MatuteErwan BezardRichard Wade-MartinsNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Nora Bengoa-Vergniory Emilie Faggiani Paula Ramos-Gonzalez Ecem Kirkiz Natalie Connor-Robson Liam V. Brown Ibrar Siddique Zizheng Li Siv Vingill Milena Cioroch Fabio Cavaliere Sarah Threlfell Bradley Roberts Thomas Schrader Frank-Gerrit Klärner Stephanie Cragg Benjamin Dehay Gal Bitan Carlos Matute Erwan Bezard Richard Wade-Martins CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s disease |
| description |
CLR01 is a molecular tweezer that inhibits protein aggregation. Here the authors show that CLR01 protects dopaminergic neurons in vitro and in vivo in human neurons and in mouse models showing potential as a disease-modifying therapy for Parkinson’s disease. |
| format |
article |
| author |
Nora Bengoa-Vergniory Emilie Faggiani Paula Ramos-Gonzalez Ecem Kirkiz Natalie Connor-Robson Liam V. Brown Ibrar Siddique Zizheng Li Siv Vingill Milena Cioroch Fabio Cavaliere Sarah Threlfell Bradley Roberts Thomas Schrader Frank-Gerrit Klärner Stephanie Cragg Benjamin Dehay Gal Bitan Carlos Matute Erwan Bezard Richard Wade-Martins |
| author_facet |
Nora Bengoa-Vergniory Emilie Faggiani Paula Ramos-Gonzalez Ecem Kirkiz Natalie Connor-Robson Liam V. Brown Ibrar Siddique Zizheng Li Siv Vingill Milena Cioroch Fabio Cavaliere Sarah Threlfell Bradley Roberts Thomas Schrader Frank-Gerrit Klärner Stephanie Cragg Benjamin Dehay Gal Bitan Carlos Matute Erwan Bezard Richard Wade-Martins |
| author_sort |
Nora Bengoa-Vergniory |
| title |
CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s disease |
| title_short |
CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s disease |
| title_full |
CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s disease |
| title_fullStr |
CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s disease |
| title_full_unstemmed |
CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s disease |
| title_sort |
clr01 protects dopaminergic neurons in vitro and in mouse models of parkinson’s disease |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/dbb405cbb99f4bdb826102e5b534b7da |
| work_keys_str_mv |
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