CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s disease
CLR01 is a molecular tweezer that inhibits protein aggregation. Here the authors show that CLR01 protects dopaminergic neurons in vitro and in vivo in human neurons and in mouse models showing potential as a disease-modifying therapy for Parkinson’s disease.
Enregistré dans:
Auteurs principaux: | Nora Bengoa-Vergniory, Emilie Faggiani, Paula Ramos-Gonzalez, Ecem Kirkiz, Natalie Connor-Robson, Liam V. Brown, Ibrar Siddique, Zizheng Li, Siv Vingill, Milena Cioroch, Fabio Cavaliere, Sarah Threlfell, Bradley Roberts, Thomas Schrader, Frank-Gerrit Klärner, Stephanie Cragg, Benjamin Dehay, Gal Bitan, Carlos Matute, Erwan Bezard, Richard Wade-Martins |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2020
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/dbb405cbb99f4bdb826102e5b534b7da |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes
par: Zizheng Li, et autres
Publié: (2021) -
Direct Target Network of the <named-content content-type="genus-species">Neurospora crassa</named-content> Plant Cell Wall Deconstruction Regulators CLR-1, CLR-2, and XLR-1
par: James P. Craig, et autres
Publié: (2015) -
Dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson’s disease and L-Dopa induced dyskinesia
par: Lauren Malave, et autres
Publié: (2021) -
Pilot Study Assessing the Impact of Intrathecal Administration of Variants AAV-PHP.B and AAV-PHP.eB on Brain Transduction in Adult Rhesus Macaques
par: Marie-Laure Arotcarena, et autres
Publié: (2021) -
Continuous requirement for the Clr4 complex but not RNAi for centromeric heterochromatin assembly in fission yeast harboring a disrupted RITS complex.
par: Sreenath Shanker, et autres
Publié: (2010)