A cysteine-based molecular code informs collagen C-propeptide assembly

Collagen proteins assemble into trimers from distinct monomers with high specificity, yet the molecular basis for this specificity remains unclear. Here the authors demonstrate the crucial role of conserved C-terminal domain cysteine residues and calcium in homotrimeric procollagen assembly.

Guardado en:

Detalles Bibliográficos
Autores principales:	Andrew S. DiChiara, Rasia C. Li, Patreece H. Suen, Azade S. Hosseini, Rebecca J. Taylor, Alexander F. Weickhardt, Diya Malhotra, Darrell R. McCaslin, Matthew D. Shoulders
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dbc3340970d64d4c9c2a223c1086ae26
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:dbc3340970d64d4c9c2a223c1086ae26
record_format	dspace
spelling	oai:doaj.org-article:dbc3340970d64d4c9c2a223c1086ae262021-12-02T15:34:20ZA cysteine-based molecular code informs collagen C-propeptide assembly10.1038/s41467-018-06185-22041-1723https://doaj.org/article/dbc3340970d64d4c9c2a223c1086ae262018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06185-2https://doaj.org/toc/2041-1723Collagen proteins assemble into trimers from distinct monomers with high specificity, yet the molecular basis for this specificity remains unclear. Here the authors demonstrate the crucial role of conserved C-terminal domain cysteine residues and calcium in homotrimeric procollagen assembly.Andrew S. DiChiaraRasia C. LiPatreece H. SuenAzade S. HosseiniRebecca J. TaylorAlexander F. WeickhardtDiya MalhotraDarrell R. McCaslinMatthew D. ShouldersNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andrew S. DiChiara Rasia C. Li Patreece H. Suen Azade S. Hosseini Rebecca J. Taylor Alexander F. Weickhardt Diya Malhotra Darrell R. McCaslin Matthew D. Shoulders A cysteine-based molecular code informs collagen C-propeptide assembly
description	Collagen proteins assemble into trimers from distinct monomers with high specificity, yet the molecular basis for this specificity remains unclear. Here the authors demonstrate the crucial role of conserved C-terminal domain cysteine residues and calcium in homotrimeric procollagen assembly.
format	article
author	Andrew S. DiChiara Rasia C. Li Patreece H. Suen Azade S. Hosseini Rebecca J. Taylor Alexander F. Weickhardt Diya Malhotra Darrell R. McCaslin Matthew D. Shoulders
author_facet	Andrew S. DiChiara Rasia C. Li Patreece H. Suen Azade S. Hosseini Rebecca J. Taylor Alexander F. Weickhardt Diya Malhotra Darrell R. McCaslin Matthew D. Shoulders
author_sort	Andrew S. DiChiara
title	A cysteine-based molecular code informs collagen C-propeptide assembly
title_short	A cysteine-based molecular code informs collagen C-propeptide assembly
title_full	A cysteine-based molecular code informs collagen C-propeptide assembly
title_fullStr	A cysteine-based molecular code informs collagen C-propeptide assembly
title_full_unstemmed	A cysteine-based molecular code informs collagen C-propeptide assembly
title_sort	cysteine-based molecular code informs collagen c-propeptide assembly
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/dbc3340970d64d4c9c2a223c1086ae26
work_keys_str_mv	AT andrewsdichiara acysteinebasedmolecularcodeinformscollagencpropeptideassembly AT rasiacli acysteinebasedmolecularcodeinformscollagencpropeptideassembly AT patreecehsuen acysteinebasedmolecularcodeinformscollagencpropeptideassembly AT azadeshosseini acysteinebasedmolecularcodeinformscollagencpropeptideassembly AT rebeccajtaylor acysteinebasedmolecularcodeinformscollagencpropeptideassembly AT alexanderfweickhardt acysteinebasedmolecularcodeinformscollagencpropeptideassembly AT diyamalhotra acysteinebasedmolecularcodeinformscollagencpropeptideassembly AT darrellrmccaslin acysteinebasedmolecularcodeinformscollagencpropeptideassembly AT matthewdshoulders acysteinebasedmolecularcodeinformscollagencpropeptideassembly AT andrewsdichiara cysteinebasedmolecularcodeinformscollagencpropeptideassembly AT rasiacli cysteinebasedmolecularcodeinformscollagencpropeptideassembly AT patreecehsuen cysteinebasedmolecularcodeinformscollagencpropeptideassembly AT azadeshosseini cysteinebasedmolecularcodeinformscollagencpropeptideassembly AT rebeccajtaylor cysteinebasedmolecularcodeinformscollagencpropeptideassembly AT alexanderfweickhardt cysteinebasedmolecularcodeinformscollagencpropeptideassembly AT diyamalhotra cysteinebasedmolecularcodeinformscollagencpropeptideassembly AT darrellrmccaslin cysteinebasedmolecularcodeinformscollagencpropeptideassembly AT matthewdshoulders cysteinebasedmolecularcodeinformscollagencpropeptideassembly
_version_	1718386868355072000

A cysteine-based molecular code informs collagen C-propeptide assembly

Ejemplares similares