An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure

An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure

During autophagy, phagophores elongate to form double-membrane vesicles but the mechanism behind their closure is unknown. Here, the authors develop an autophagy assay and find a role for the endosomal sorting complexes required for transport component CHMP2A as a phagophore closure regulator.

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Bibliographic Details
Main Authors: Yoshinori Takahashi, Haiyan He, Zhenyuan Tang, Tatsuya Hattori, Ying Liu, Megan M. Young, Jacob M. Serfass, Longgui Chen, Melat Gebru, Chong Chen, Carson A. Wills, Jennifer M. Atkinson, Han Chen, Thomas Abraham, Hong-Gang Wang
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Science
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Online Access:https://doaj.org/article/dc0bd3a5e9b64caca02caa285ccc24af
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https://doaj.org/article/dc0bd3a5e9b64caca02caa285ccc24af

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