An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure
During autophagy, phagophores elongate to form double-membrane vesicles but the mechanism behind their closure is unknown. Here, the authors develop an autophagy assay and find a role for the endosomal sorting complexes required for transport component CHMP2A as a phagophore closure regulator.
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Nature Portfolio
2018
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oai:doaj.org-article:dc0bd3a5e9b64caca02caa285ccc24af2021-12-02T15:34:24ZAn autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure10.1038/s41467-018-05254-w2041-1723https://doaj.org/article/dc0bd3a5e9b64caca02caa285ccc24af2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05254-whttps://doaj.org/toc/2041-1723During autophagy, phagophores elongate to form double-membrane vesicles but the mechanism behind their closure is unknown. Here, the authors develop an autophagy assay and find a role for the endosomal sorting complexes required for transport component CHMP2A as a phagophore closure regulator.Yoshinori TakahashiHaiyan HeZhenyuan TangTatsuya HattoriYing LiuMegan M. YoungJacob M. SerfassLonggui ChenMelat GebruChong ChenCarson A. WillsJennifer M. AtkinsonHan ChenThomas AbrahamHong-Gang WangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Yoshinori Takahashi Haiyan He Zhenyuan Tang Tatsuya Hattori Ying Liu Megan M. Young Jacob M. Serfass Longgui Chen Melat Gebru Chong Chen Carson A. Wills Jennifer M. Atkinson Han Chen Thomas Abraham Hong-Gang Wang An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure |
| description |
During autophagy, phagophores elongate to form double-membrane vesicles but the mechanism behind their closure is unknown. Here, the authors develop an autophagy assay and find a role for the endosomal sorting complexes required for transport component CHMP2A as a phagophore closure regulator. |
| format |
article |
| author |
Yoshinori Takahashi Haiyan He Zhenyuan Tang Tatsuya Hattori Ying Liu Megan M. Young Jacob M. Serfass Longgui Chen Melat Gebru Chong Chen Carson A. Wills Jennifer M. Atkinson Han Chen Thomas Abraham Hong-Gang Wang |
| author_facet |
Yoshinori Takahashi Haiyan He Zhenyuan Tang Tatsuya Hattori Ying Liu Megan M. Young Jacob M. Serfass Longgui Chen Melat Gebru Chong Chen Carson A. Wills Jennifer M. Atkinson Han Chen Thomas Abraham Hong-Gang Wang |
| author_sort |
Yoshinori Takahashi |
| title |
An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure |
| title_short |
An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure |
| title_full |
An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure |
| title_fullStr |
An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure |
| title_full_unstemmed |
An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure |
| title_sort |
autophagy assay reveals the escrt-iii component chmp2a as a regulator of phagophore closure |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/dc0bd3a5e9b64caca02caa285ccc24af |
| work_keys_str_mv |
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| _version_ |
1718386868802813952 |