αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells

αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells

Integrins can regulate antigen-specific and innate immune receptor signalling, thereby affecting immune cell function. Here the authors show that avß3 integrin controls Toll-like receptor (TLR) signalling by regulating its trafficking to limit TLR-mediated B-cell proliferation and antibody productio...

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Main Authors: Mridu Acharya, Anna Sokolovska, Jenny M. Tam, Kara L. Conway, Caroline Stefani, Fiona Raso, Subhankar Mukhopadhyay, Marianela Feliu, Elahna Paul, John Savill, Richard O. Hynes, Ramnik J. Xavier, Jatin M. Vyas, Lynda M. Stuart, Adam Lacy-Hulbert
Format: article
Language:EN
Published: Nature Portfolio 2016
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Science
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Online Access:https://doaj.org/article/dc8efeea8b80409f8e4a56aef9dd4da0
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Summary:Integrins can regulate antigen-specific and innate immune receptor signalling, thereby affecting immune cell function. Here the authors show that avß3 integrin controls Toll-like receptor (TLR) signalling by regulating its trafficking to limit TLR-mediated B-cell proliferation and antibody production.

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