αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells

Integrins can regulate antigen-specific and innate immune receptor signalling, thereby affecting immune cell function. Here the authors show that avß3 integrin controls Toll-like receptor (TLR) signalling by regulating its trafficking to limit TLR-mediated B-cell proliferation and antibody productio...

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Main Authors:	Mridu Acharya, Anna Sokolovska, Jenny M. Tam, Kara L. Conway, Caroline Stefani, Fiona Raso, Subhankar Mukhopadhyay, Marianela Feliu, Elahna Paul, John Savill, Richard O. Hynes, Ramnik J. Xavier, Jatin M. Vyas, Lynda M. Stuart, Adam Lacy-Hulbert
Format:	article
Language:	EN
Published:	Nature Portfolio 2016
Subjects:	Science Q
Online Access:	https://doaj.org/article/dc8efeea8b80409f8e4a56aef9dd4da0
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spelling	oai:doaj.org-article:dc8efeea8b80409f8e4a56aef9dd4da02021-12-02T14:39:11Zαv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells10.1038/ncomms109172041-1723https://doaj.org/article/dc8efeea8b80409f8e4a56aef9dd4da02016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10917https://doaj.org/toc/2041-1723Integrins can regulate antigen-specific and innate immune receptor signalling, thereby affecting immune cell function. Here the authors show that avß3 integrin controls Toll-like receptor (TLR) signalling by regulating its trafficking to limit TLR-mediated B-cell proliferation and antibody production.Mridu AcharyaAnna SokolovskaJenny M. TamKara L. ConwayCaroline StefaniFiona RasoSubhankar MukhopadhyayMarianela FeliuElahna PaulJohn SavillRichard O. HynesRamnik J. XavierJatin M. VyasLynda M. StuartAdam Lacy-HulbertNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mridu Acharya Anna Sokolovska Jenny M. Tam Kara L. Conway Caroline Stefani Fiona Raso Subhankar Mukhopadhyay Marianela Feliu Elahna Paul John Savill Richard O. Hynes Ramnik J. Xavier Jatin M. Vyas Lynda M. Stuart Adam Lacy-Hulbert αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells
description	Integrins can regulate antigen-specific and innate immune receptor signalling, thereby affecting immune cell function. Here the authors show that avß3 integrin controls Toll-like receptor (TLR) signalling by regulating its trafficking to limit TLR-mediated B-cell proliferation and antibody production.
format	article
author	Mridu Acharya Anna Sokolovska Jenny M. Tam Kara L. Conway Caroline Stefani Fiona Raso Subhankar Mukhopadhyay Marianela Feliu Elahna Paul John Savill Richard O. Hynes Ramnik J. Xavier Jatin M. Vyas Lynda M. Stuart Adam Lacy-Hulbert
author_facet	Mridu Acharya Anna Sokolovska Jenny M. Tam Kara L. Conway Caroline Stefani Fiona Raso Subhankar Mukhopadhyay Marianela Feliu Elahna Paul John Savill Richard O. Hynes Ramnik J. Xavier Jatin M. Vyas Lynda M. Stuart Adam Lacy-Hulbert
author_sort	Mridu Acharya
title	αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells
title_short	αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells
title_full	αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells
title_fullStr	αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells
title_full_unstemmed	αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells
title_sort	αv integrins combine with lc3 and atg5 to regulate toll-like receptor signalling in b cells
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/dc8efeea8b80409f8e4a56aef9dd4da0
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αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells

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