Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models

NSAID-induced analgesia is typically induced by inhibition of COX enzymes. Here the authors show instead that fenamate NSAIDs inhibit the Nlrp3 inflammasome via an effect on volume-regulated anion channel function and also repurpose these drugs for therapeutic effect in rodent models of Alzheimer di...

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Autores principales:	Michael J. D. Daniels, Jack Rivers-Auty, Tom Schilling, Nicholas G. Spencer, William Watremez, Victoria Fasolino, Sophie J. Booth, Claire S. White, Alex G. Baldwin, Sally Freeman, Raymond Wong, Clare Latta, Shi Yu, Joshua Jackson, Nicolas Fischer, Violette Koziel, Thierry Pillot, James Bagnall, Stuart M. Allan, Pawel Paszek, James Galea, Michael K. Harte, Claudia Eder, Catherine B. Lawrence, David Brough
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dca8360eb57c4ee588985f6c192c8a0c
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spelling	oai:doaj.org-article:dca8360eb57c4ee588985f6c192c8a0c2021-12-02T15:34:08ZFenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models10.1038/ncomms125042041-1723https://doaj.org/article/dca8360eb57c4ee588985f6c192c8a0c2016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12504https://doaj.org/toc/2041-1723NSAID-induced analgesia is typically induced by inhibition of COX enzymes. Here the authors show instead that fenamate NSAIDs inhibit the Nlrp3 inflammasome via an effect on volume-regulated anion channel function and also repurpose these drugs for therapeutic effect in rodent models of Alzheimer disease.Michael J. D. DanielsJack Rivers-AutyTom SchillingNicholas G. SpencerWilliam WatremezVictoria FasolinoSophie J. BoothClaire S. WhiteAlex G. BaldwinSally FreemanRaymond WongClare LattaShi YuJoshua JacksonNicolas FischerViolette KozielThierry PillotJames BagnallStuart M. AllanPawel PaszekJames GaleaMichael K. HarteClaudia EderCatherine B. LawrenceDavid BroughNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael J. D. Daniels Jack Rivers-Auty Tom Schilling Nicholas G. Spencer William Watremez Victoria Fasolino Sophie J. Booth Claire S. White Alex G. Baldwin Sally Freeman Raymond Wong Clare Latta Shi Yu Joshua Jackson Nicolas Fischer Violette Koziel Thierry Pillot James Bagnall Stuart M. Allan Pawel Paszek James Galea Michael K. Harte Claudia Eder Catherine B. Lawrence David Brough Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models
description	NSAID-induced analgesia is typically induced by inhibition of COX enzymes. Here the authors show instead that fenamate NSAIDs inhibit the Nlrp3 inflammasome via an effect on volume-regulated anion channel function and also repurpose these drugs for therapeutic effect in rodent models of Alzheimer disease.
format	article
author	Michael J. D. Daniels Jack Rivers-Auty Tom Schilling Nicholas G. Spencer William Watremez Victoria Fasolino Sophie J. Booth Claire S. White Alex G. Baldwin Sally Freeman Raymond Wong Clare Latta Shi Yu Joshua Jackson Nicolas Fischer Violette Koziel Thierry Pillot James Bagnall Stuart M. Allan Pawel Paszek James Galea Michael K. Harte Claudia Eder Catherine B. Lawrence David Brough
author_facet	Michael J. D. Daniels Jack Rivers-Auty Tom Schilling Nicholas G. Spencer William Watremez Victoria Fasolino Sophie J. Booth Claire S. White Alex G. Baldwin Sally Freeman Raymond Wong Clare Latta Shi Yu Joshua Jackson Nicolas Fischer Violette Koziel Thierry Pillot James Bagnall Stuart M. Allan Pawel Paszek James Galea Michael K. Harte Claudia Eder Catherine B. Lawrence David Brough
author_sort	Michael J. D. Daniels
title	Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models
title_short	Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models
title_full	Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models
title_fullStr	Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models
title_full_unstemmed	Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models
title_sort	fenamate nsaids inhibit the nlrp3 inflammasome and protect against alzheimer’s disease in rodent models
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/dca8360eb57c4ee588985f6c192c8a0c
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Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models

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