Platelet-Mediated NET Release Amplifies Coagulopathy and Drives Lung Pathology During Severe Influenza Infection

Platelet-Mediated NET Release Amplifies Coagulopathy and Drives Lung Pathology During Severe Influenza Infection

The influenza A virus (IAV) causes a respiratory tract infection with approximately 10% of the population infected by the virus each year. Severe IAV infection is characterized by excessive inflammation and tissue pathology in the lungs. Platelet and neutrophil recruitment to the lung are involved i...

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Autores principales: Seok-Joo Kim, Agostina Carestia, Braedon McDonald, Amanda Z. Zucoloto, Heidi Grosjean, Rachelle P. Davis, Madison Turk, Victor Naumenko, Silvio Antoniak, Nigel Mackman, Mohamed Sarjoon Abdul-Cader, Mohamed Faizal Abdul-Careem, Morley D. Hollenberg, Craig N. Jenne
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
Materias:
influenza A virus
platelets
PAR4
thrombin
neutrophils
NETs
Immunologic diseases. Allergy
RC581-607
Acceso en línea:https://doaj.org/article/dca945b9c1d943fb8ab37151fffb8218
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https://doaj.org/article/dca945b9c1d943fb8ab37151fffb8218

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