PHYTOCHEMICAL CHARACTERIZATION OF A BIFLAVONOID FRACTION FROM <I>Garcinia madruno</I>: INHIBITION OF HUMAN LDL OXIDATION AND ITS FREE RADICAL SCAVENGING MECHANISM

The inhibitory LDL oxidation potential and free radical stabilization capacity of a characterized biflavonoid fraction (FB) was evaluated and correlated by its biflavonoid content. Morelloflavone, volkensiflavone and amentoflavone were identified in the FB. The extract containing the FB (AcOEt extr...

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Auteurs principaux:	Edison OSORIO D., Guillermo Montoya P., Jaume Bastida
Format:	article
Langue:	EN
Publié:	Universidad de Antioquia 2009
Sujets:	Garcinia madruno Clusiaceae biflavonoids antioxidant DPPH lipid peroxidation Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Accès en ligne:	https://doaj.org/article/dccd36e8debe496e8274f7725ed6e43d
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spelling	oai:doaj.org-article:dccd36e8debe496e8274f7725ed6e43d2021-11-19T04:14:52ZPHYTOCHEMICAL CHARACTERIZATION OF A BIFLAVONOID FRACTION FROM <I>Garcinia madruno</I>: INHIBITION OF HUMAN LDL OXIDATION AND ITS FREE RADICAL SCAVENGING MECHANISM0121-40042145-2660https://doaj.org/article/dccd36e8debe496e8274f7725ed6e43d2009-11-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/3016https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660 The inhibitory LDL oxidation potential and free radical stabilization capacity of a characterized biflavonoid fraction (FB) was evaluated and correlated by its biflavonoid content. Morelloflavone, volkensiflavone and amentoflavone were identified in the FB. The extract containing the FB (AcOEt extract) was found to be the major contributor to the free radical-scavenging activity of G. madruno. The DPPH activity for the FB was 4.50 μg/mL. Lipid peroxidation, induced with CuSO4, was significantly reduced in the presence of the FB (CE50 = 11.85 μg/mL). Morelloflavone was found to be the main biflavonoid in the fraction responsible for its protection against lipid peroxidation and free radical-scavenging activity, although processes of synergy are possible. These properties suggest that the FB of G. madruno is an excellent candidate for use as an antioxidant. Edison OSORIO D.Guillermo Montoya P.Jaume BastidaUniversidad de AntioquiaarticleGarcinia madrunoClusiaceaebiflavonoidsantioxidantDPPHlipid peroxidationFood processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 16, Iss 3 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Garcinia madruno Clusiaceae biflavonoids antioxidant DPPH lipid peroxidation Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	Garcinia madruno Clusiaceae biflavonoids antioxidant DPPH lipid peroxidation Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Edison OSORIO D. Guillermo Montoya P. Jaume Bastida PHYTOCHEMICAL CHARACTERIZATION OF A BIFLAVONOID FRACTION FROM <I>Garcinia madruno</I>: INHIBITION OF HUMAN LDL OXIDATION AND ITS FREE RADICAL SCAVENGING MECHANISM
description	The inhibitory LDL oxidation potential and free radical stabilization capacity of a characterized biflavonoid fraction (FB) was evaluated and correlated by its biflavonoid content. Morelloflavone, volkensiflavone and amentoflavone were identified in the FB. The extract containing the FB (AcOEt extract) was found to be the major contributor to the free radical-scavenging activity of G. madruno. The DPPH activity for the FB was 4.50 μg/mL. Lipid peroxidation, induced with CuSO4, was significantly reduced in the presence of the FB (CE50 = 11.85 μg/mL). Morelloflavone was found to be the main biflavonoid in the fraction responsible for its protection against lipid peroxidation and free radical-scavenging activity, although processes of synergy are possible. These properties suggest that the FB of G. madruno is an excellent candidate for use as an antioxidant.
format	article
author	Edison OSORIO D. Guillermo Montoya P. Jaume Bastida
author_facet	Edison OSORIO D. Guillermo Montoya P. Jaume Bastida
author_sort	Edison OSORIO D.
title	PHYTOCHEMICAL CHARACTERIZATION OF A BIFLAVONOID FRACTION FROM <I>Garcinia madruno</I>: INHIBITION OF HUMAN LDL OXIDATION AND ITS FREE RADICAL SCAVENGING MECHANISM
title_short	PHYTOCHEMICAL CHARACTERIZATION OF A BIFLAVONOID FRACTION FROM <I>Garcinia madruno</I>: INHIBITION OF HUMAN LDL OXIDATION AND ITS FREE RADICAL SCAVENGING MECHANISM
title_full	PHYTOCHEMICAL CHARACTERIZATION OF A BIFLAVONOID FRACTION FROM <I>Garcinia madruno</I>: INHIBITION OF HUMAN LDL OXIDATION AND ITS FREE RADICAL SCAVENGING MECHANISM
title_fullStr	PHYTOCHEMICAL CHARACTERIZATION OF A BIFLAVONOID FRACTION FROM <I>Garcinia madruno</I>: INHIBITION OF HUMAN LDL OXIDATION AND ITS FREE RADICAL SCAVENGING MECHANISM
title_full_unstemmed	PHYTOCHEMICAL CHARACTERIZATION OF A BIFLAVONOID FRACTION FROM <I>Garcinia madruno</I>: INHIBITION OF HUMAN LDL OXIDATION AND ITS FREE RADICAL SCAVENGING MECHANISM
title_sort	phytochemical characterization of a biflavonoid fraction from <i>garcinia madruno</i>: inhibition of human ldl oxidation and its free radical scavenging mechanism
publisher	Universidad de Antioquia
publishDate	2009
url	https://doaj.org/article/dccd36e8debe496e8274f7725ed6e43d
work_keys_str_mv	AT edisonosoriod phytochemicalcharacterizationofabiflavonoidfractionfromigarciniamadrunoiinhibitionofhumanldloxidationanditsfreeradicalscavengingmechanism AT guillermomontoyap phytochemicalcharacterizationofabiflavonoidfractionfromigarciniamadrunoiinhibitionofhumanldloxidationanditsfreeradicalscavengingmechanism AT jaumebastida phytochemicalcharacterizationofabiflavonoidfractionfromigarciniamadrunoiinhibitionofhumanldloxidationanditsfreeradicalscavengingmechanism
_version_	1718420469294563328

PHYTOCHEMICAL CHARACTERIZATION OF A BIFLAVONOID FRACTION FROM <I>Garcinia madruno</I>: INHIBITION OF HUMAN LDL OXIDATION AND ITS FREE RADICAL SCAVENGING MECHANISM

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