GGA2 interacts with EGFR cytoplasmic domain to stabilize the receptor expression and promote cell growth

Abstract Epidermal growth factor receptor (EGFR) signaling and its downregulation upon ligand binding have been extensively documented. However, the mechanisms by which cells maintain steady-state EGFR expression remain poorly understood. Here, we report a novel role of Golgi-localized, γ-adaptin ea...

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Autores principales: Takefumi Uemura, Satoshi Kametaka, Satoshi Waguri
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/dcd67bdd63cd413c9edfbc3b02b1c99f
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