GGA2 interacts with EGFR cytoplasmic domain to stabilize the receptor expression and promote cell growth

Abstract Epidermal growth factor receptor (EGFR) signaling and its downregulation upon ligand binding have been extensively documented. However, the mechanisms by which cells maintain steady-state EGFR expression remain poorly understood. Here, we report a novel role of Golgi-localized, γ-adaptin ea...

Full description

Saved in:
Bibliographic Details
Main Authors: Takefumi Uemura, Satoshi Kametaka, Satoshi Waguri
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
R
Q
Online Access:https://doaj.org/article/dcd67bdd63cd413c9edfbc3b02b1c99f
Tags: Add Tag
No Tags, Be the first to tag this record!